Effects of thyroxin therapy on cardiac function in patients with subclinical hypothyroidism: Index of myocardial performance in the evaluation of left ventricular function

dc.authorid0000-0002-9685-4486
dc.authorid0000-0002-8877-3520
dc.contributor.authorYazıcı, Mehmet
dc.contributor.authorGörgülü, Şevket
dc.contributor.authorSertbaş, Yaşar
dc.contributor.authorErbilen, Enver
dc.contributor.authorAlbayrak, Sinan
dc.contributor.authorYıldız, Özcan
dc.contributor.authorUyan, Cihangir
dc.date.accessioned2021-06-23T18:54:36Z
dc.date.available2021-06-23T18:54:36Z
dc.date.issued2004
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractObjective: We investigated the effects of thyroxine (T4) therapy on the cardiac function in subclinical hypothyroidism (SHT) by using the index of myocardial performance (IMP) and the conventional echocardiographic parameters. Methods: Forty-five SHT patients (F/M:38/7, age 39.9±7.9) and 29 healthy subjects (F/M:25/4, age 38.3±8.6) were studied. Patients were randomly assigned, in a double-blind manner to receive T4 therapy (group I) or a placebo (group II) and for a period of up to 12 months, were followed up using thyroid function tests and both conventional and Doppler echocardiographic measurements. Results: At the baseline, the SHT patients has a significantly higher isovolumic relaxation time (IRT) (98.3±23.7 vs. 81.7±14.7<0.01) , IMP (0.52±0.06 vs. 0.42±0.05; P<0.001), A max (late mitral peak velocity) (83.4±12.6 vs. 74.3±13.5; P<0.01) and significantly lower (early mitral peak velocity) Emax/Amax ratio (1.19±0.18 vs. 1.34±0.17; P<0.01) than the individuals in the control group. In group I, the thyroid hormone profile became normalized after 1 year of L-T4 therapy, but there was no significant change in the left ventricular (LV) morphology or systolic function. After 1 year of follow-up, group I showed a significant reduction of MPI (0.53±0.05 vs. 0.42±0.07; P<0.001), Amax (84.2±13.7 vs. 74.5±11; P<0.001) and IRT (98.6±23.7 vs. 82.9± 23.3; P<0.001) along with a normalization of the E/A ratio (1.17±0.16 vs. 1.33±0.19; P<0.001). Conversely, no change was observed in group II. Conclusions: An impairment of left ventricular diastolic function, which may be reversible with T4 therapy, was observed in the SHT patients, and IMP may be useful in the evaluation of LV myocardial dysfunction in these patients. © 2003 Elsevier Ireland Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.ijcard.2003.05.015
dc.identifier.endpage143en_US
dc.identifier.issn0167-5273
dc.identifier.issue2-3en_US
dc.identifier.pmid15193811en_US
dc.identifier.scopus2-s2.0-2942519733en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage135en_US
dc.identifier.urihttps://doi.org/10.1016/j.ijcard.2003.05.015
dc.identifier.urihttps://hdl.handle.net/20.500.12491/4504
dc.identifier.volume95en_US
dc.identifier.wosWOS:000222169900004en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorYazıcı, Mehmet
dc.institutionauthorSertbaş, Yaşar
dc.institutionauthorErbilen, Enver
dc.institutionauthorAlbayrak, Sinan
dc.institutionauthorYıldız, Özcan
dc.institutionauthorYıldız, Özcan
dc.language.isoenen_US
dc.relation.ispartofInternational Journal of Cardiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCardiac functionen_US
dc.subjectSubclinical hypothyroidismen_US
dc.subjectThyroxin therapyen_US
dc.titleEffects of thyroxin therapy on cardiac function in patients with subclinical hypothyroidism: Index of myocardial performance in the evaluation of left ventricular functionen_US
dc.typeArticleen_US

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