Nuclear factor-kappa B inhibitors abolish hypoxic vasoconstriction in sheep-isolated pulmonary arteries
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Dosyalar
Tarih
2003
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier Science Bv
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The aim of this study was to determine the role of nuclear factor-kappaB (NF-kappaB) in hypoxic constriction of isolated pulmonary arteries. Rings were suspended in an organ bath filled with Krebs-Henseleit solution and isometric contractions were recorded continuously. Hypoxia (%95 N-2-%5 CO2) had no marked effect on resting force in artery rings. However, hypoxia caused further contractions in serotonin-precontracted arteries. Hypoxia-induced vasoconstrictions were abolished by preincubation with NF-kappaB inhibitors, pyrrolidine dithiocarbamate (100 muM) or pyrithione (10 muM). These results suggest that reactive oxygen species and/or NF-kappaB activation may be involved in the hypoxia-induced vasoconstriction in sheep-isolated pulmonary arteries.
Açıklama
Anahtar Kelimeler
Hypoxia, Pulmonary Artery, Sheep, Pyrrolidine Dithiocarbamate, Pyrithione
Kaynak
European Journal Of Pharmacology
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
458
Sayı
1-2
