Comparison of preseptal and pretarsal onabotulinum toxin an injection in patients with hemifacial spasm

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dc.authorid0000-0003-3277-7992
dc.authorid0000-0002-5308-4653
dc.authorid0000-0003-3582-2832
dc.contributor.authorYılmaz, Ayşen Tuğba Canbasoğlu
dc.contributor.authorYılmaz, Murat
dc.contributor.authorÖztekin, Mehmet Fevzi
dc.date.accessioned2021-06-23T19:17:11Z
dc.date.available2021-06-23T19:17:11Z
dc.date.issued2020
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractAim: The aim of the present study was to evaluate the effects of different doses of onabotulinum toxin A on the amplitude and latency values of the blink reflex and facial nerve in the pretarsal and preseptal portions of the orbicularis oculi muscle in patients with hemifacial spasm. Materials and methods: Thirty patients with hemifacial spasm were assigned in two equal groups: Pretarsal Group: Five units of onabotulinum toxin A were injected into each of 2 points of the pretarsal portion; Preseptal Group: Five units of onabotulinum toxin A was injected into 4 points of the preseptal portion. We compared the electromyographic features of the patients before and 5 weeks after botulinum toxin (BTX) injection. Results: In comparison of pre- and post-treatment measurements of blink reflex amplitude responses, the decreases in R1 (p = 0.003), R2 (p < 0.001), and R2C amplitudes (p = 0.031) were found to be significant in the BTX injected side in the pretarsal group. In the comparison of pre- and post-treatment measurements of facial nerve compound action potential amplitude changes, decreases in the amplitudes of the BTX injected (ipsilateral), and uninjected (contralateral) side in the pretarsal group were found to be significant (p < 0.001 for both groups). Decreases in the amplitudes of the BTX injected, and uninjected side in the preseptal group were found to be significant (p < 0.001, and p = 0.008, respectively). Conclusion: According to our hypothesis, the smaller amount of BTX applied to the pretarsal portion was found to be more effective than higher amount of BTX injected into the preseptal portion of the orbicularis oculi muscle.en_US
dc.identifier.doi10.1080/00207454.2020.1750389
dc.identifier.endpage554
dc.identifier.issn0020-7454
dc.identifier.issue6
dc.identifier.pmid32233985en_US
dc.identifier.scopus2-s2.0-85083515865en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage549
dc.identifier.urihttps://doi.org/10.1080/00207454.2020.1750389
dc.identifier.urihttps://hdl.handle.net/20.500.12491/5274
dc.identifier.volume131
dc.identifier.wosWOS:000561172500001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorYılmaz, Ayşen Tuğba Canbasoğlu
dc.institutionauthorYılmaz, Murat
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofInternational Journal Of Neuroscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHemifacial Spasmen_US
dc.subjectOnabotulinum Toxin Aen_US
dc.subjectOrbicularis Oculi Muscleen_US
dc.subjectPreseptalen_US
dc.subjectPretarsalen_US
dc.titleComparison of preseptal and pretarsal onabotulinum toxin an injection in patients with hemifacial spasmen_US
dc.typeArticleen_US

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