Assessment of Epstein-Barr virus, Candida albicans, and some periodontal pathogens in rheumatoid arthritis patients with periodontitis

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dc.authorid0000-0001-6204-7304en_US
dc.authorid0000-0002-4205-861Xen_US
dc.authorid0000-0002-4635-5179en_US
dc.authorid0000-0001-9670-2426en_US
dc.authorid0000-0002-5411-5925en_US
dc.authorid0000-0001-6715-8388en_US
dc.contributor.authorPaksoy, Tuğçe
dc.contributor.authorUstaoğlu, Gülbahar
dc.contributor.authorTaşçı, Murat
dc.contributor.authorDemirci, Mehmet
dc.contributor.authorÜnlü, Özge
dc.contributor.authorYaşar, Mustafa Fatih
dc.date.accessioned2024-05-30T11:53:01Z
dc.date.available2024-05-30T11:53:01Z
dc.date.issued2023en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractOBJECTIVE: To comparatively investigate the periodontal results and microbial load in subgingival biofilm samples (SBS) in rheumatoid arthritis subjects and healthy volunteers.METHODS: One hundred twenty subjects were classified into different cohorts: healthy (H-C); periodontitis with good systemic health (H-P); rheumatoid arthritis (RA) and good periodontal health (RA-C); and periodontitis with RA (RA-P). The periodontal parameters were recorded, and SBS were collected to determine periodontal pathogens including Epstein-Barr Virus (EBV) and Candida albicans using reverse transcription-polymerase chain reaction (RT-PCR). RESULTS: Subjects that had greater disease course, determined by moderate or high disease activity scores 28 (DAS28), suffered from worse oral health conditions (higher plaque index, gingival index, bleeding on probing, probing depth, and excessive clinical attachment loss) than those with low DAS28 scores. A higher prevalence of Treponema denticola (T. denticola) was observed in the RA-P group. Cyclic citrullinated peptide was associated with the occurrence of T. denticola and Campylo-bacter rectus. DAS28 using C-reactive protein (DAS28-CRP) had a significant association with Capnocytophaga gingivalis and EBV. The duration of the RA disease was associated with the presence of T. denticola.CONCLUSION: Subgingival microbial difference could reliably discriminate RA from healthy individuals. Especially, T. denti-cola and EBV may play a key role in periodontitis associated with RA.en_US
dc.identifier.citationPaksoy, T., Ustaoglu, G., Tasci, M., Demirci, M., Unlu, O., & Yasar, M. F. (2023). Assessment of Epstein--Barr virus, Candida albicans, and some periodontal pathogens in rheumatoid arthritis patients with periodontitis. Northern Clinics of Istanbul, 10(4).en_US
dc.identifier.doi10.14744/nci.2023.58998
dc.identifier.endpage500en_US
dc.identifier.issn2148-4902
dc.identifier.issn2536-4553
dc.identifier.issue4en_US
dc.identifier.pmid37719252en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage490en_US
dc.identifier.trdizinid1242433en_US
dc.identifier.urihttp://dx.doi.org/10.14744/nci.2023.58998
dc.identifier.urihttps://hdl.handle.net/20.500.12491/12189
dc.identifier.volume10en_US
dc.identifier.wosWOS:001089160600012en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorTaşçı, Murat
dc.institutionauthorYaşar, Mustafa Fatih
dc.language.isoenen_US
dc.publisherKare Publ.en_US
dc.relation.ispartofNorthern Clinics of Istanbulen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDAS28en_US
dc.subjectMicrobiotaen_US
dc.subjectPeriodontitisen_US
dc.subjectRheumatoid Arthritisen_US
dc.subjectPerı-Implant Diseasesen_US
dc.subject2017 World Workshopen_US
dc.titleAssessment of Epstein-Barr virus, Candida albicans, and some periodontal pathogens in rheumatoid arthritis patients with periodontitisen_US
dc.typeArticleen_US

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