Esculetin alleviates pentylenetetrazole-induced seizures, cognitive impairment and pro-inflammatory cytokines and suppresses penicillin-induced epileptiform activity in rats

Basit Öğe Kaydı
dc.authorid0000-0002-1795-5677en_US
dc.authorid0000-0001-7035-3336en_US
dc.authorid0000-0001-9261-2634en_US
dc.contributor.authorDanış, Ayşegül
dc.contributor.authorKılınç, Yasemin Baranoğlu
dc.contributor.authorTorun, İbrahim Ethem
dc.contributor.authorHancı, Fatma
dc.contributor.authorKılınç, Erkan
dc.contributor.authorAnkaralı, Handan
dc.date.accessioned2023-07-26T07:45:03Z
dc.date.available2023-07-26T07:45:03Z
dc.date.issued2023en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractAims: To investigate the effects of different doses of esculetin on epileptiform activity, behavioral seizures, memory impairment, and cortical and hippocampal NF-Kappa B, as a mediator of pro-inflammatory gene induction, and pro-inflammatory cytokines in penicillin-and pentylenetetrazole(PTZ)-induced seizure models in rats. Main methods: Different doses of esculetin (5, 10, and 20 mg/kg), and diazepam (5 mg/kg) as a positive control, were tested in penicillin-and pentylenetetrazole(PTZ)-induced seizure models. In the PTZ model, cognitive function, behavioral seizures, and cortical and hippocampal pro-inflammatory biomarkers and survival factor was evaluated. In the penicillin model, the frequency and amplitude of electrophysiological epileptiform activity were assessed. Key findings: In the PTZ model, the 10 mg/kg esculetin displayed anticonvulsant effects by extending onset-times of myoclonic-jerk and generalized tonic-clonic seizure, and by diminishing seizure severity and duration of generalized tonic-clonic seizure. It also ameliorated PTZ-induced cognitive impairment, and cortical and hip-pocampal activin-A, IL-1 beta, IL-6 and NF-Kappa B levels. In the penicillin model, the 10 mg/kg esculetin decreased the frequency of spikes without changing the amplitude of spikes. As a positive-control, diazepam reversed all changes induced by both PTZ and penicillin. Significance: Esculetin exhibits anticonvulsant and memory-improving effects by alleviating the behavioral and electrophysiological characteristics of epileptic seizures. Additionally, esculetin exerts anti-neuroinflammatory actions in the PTZ-induced seizures model. Thus, esculetin may be a multi-targeted promising agent with anti-convulsant and anti-neuroinflammatory effects in the treatment of epilepsy.en_US
dc.identifier.citationDanis, A., Kilinc, Y. B., Torun, I. E., Hanci, F., Kilinc, E., & Ankarali, H. (2023). Esculetin alleviates pentylenetetrazole-induced seizures, cognitive impairment and pro-inflammatory cytokines and suppresses penicillin-induced epileptiform activity in rats. Life Sciences, 313, 121300.en_US
dc.identifier.doi10.1016/j.lfs.2022.121300
dc.identifier.endpage11en_US
dc.identifier.issn0024-3205
dc.identifier.issn1879-0631
dc.identifier.pmid36535399en_US
dc.identifier.scopus2-s2.0-85144294636en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1en_US
dc.identifier.urihttp://dx.doi.org/10.1016/j.lfs.2022.121300
dc.identifier.urihttps://hdl.handle.net/20.500.12491/11352
dc.identifier.volume313en_US
dc.identifier.wosWOS:000909684400001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorTorun, İbrahim Ethem
dc.institutionauthorHancı, Fatma
dc.institutionauthorKılınç, Erkan
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofLife Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEsculetinen_US
dc.subjectEpilepsyen_US
dc.subjectSeizuresen_US
dc.subjectEpileptiform Activityen_US
dc.subjectNeuroinflammationen_US
dc.subjectCognitive Behavioren_US
dc.titleEsculetin alleviates pentylenetetrazole-induced seizures, cognitive impairment and pro-inflammatory cytokines and suppresses penicillin-induced epileptiform activity in ratsen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
aysegul-danis.pdf
Boyut:
2.66 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin/Full Text
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
Temel Tıp Bilimleri Bölümü Koleksiyonu