Reduction of carbon tetrachloride-induced nephropathy by melatonin administration

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dc.authorid0000-0003-0754-8901en_US
dc.authorid0000-0002-5744-4812en_US
dc.authorid0000-0002-3194-267X
dc.authorid0000-0002-1197-2468
dc.authorid0000-0001-5387-2628
dc.contributor.authorÖgetürk, Murat
dc.contributor.authorKuş, İlter
dc.contributor.authorKavaklı, Ahmet
dc.contributor.authorÖner, Jale
dc.contributor.authorKükner, Aysel
dc.contributor.authorSarsılmaz, Mustafa
dc.date.accessioned2021-06-23T19:18:30Z
dc.date.available2021-06-23T19:18:30Z
dc.date.issued2005
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractThe aim of this study was to investigate possible protective effects of melatonin on carbon tetrachloride (CCl4)-induced renal damage in rats. A total of 24 animals were divided into three equal groups: the control rats received pure olive oil subcutaneously, rats in the second group were injected with CCl4 (0.5 ml kg(-1) s.c. in olive oil) and rats in the third group were injected with CCl4 (0.5 ml kg(-1)) plus melatonin (25 mg kg(-1), s.c. in 10% ethanol) every other day for 1 month. At the end of the experimental period, the animals were sacrificed and blood samples were collected. The kidneys were removed and weighed. Urea and creatinine levels were determined in blood samples. Histopathological examination of the kidney was performed using light microscopic methods. Administration Of CCl4 significantly increased relative kidney weight (g per 100 g body weight) and decreased serum urea levels compared to controls (p < 0.01). Melatonin treatment significantly (p < 0.01) reduced relative kidney weight, and it produced a statistically equal (p = 0.268) relative weight with the kidneys of control rats. CCl4 administration alone also caused histopathologically prominent damage in the kidney compared to the control group. Glomerular and tubular degeneration, interstitial mononuclear cell infiltration and fibrosis, vascular congestion around the tubules, and interstitial haemorrhage in perivascular areas were observed in the renal cortex and cortico-medullary border. However, the affect Of CCl4 on the medulla was limited. Melatonin provided protection against CCl4-induced renal toxicity as was evident by histopathological evaluation. In view of the present findings, it is suggested that melatonin protects kidneys against CCl4 toxicity.en_US
dc.identifier.doi10.1002/cbf.1166
dc.identifier.endpage92en_US
dc.identifier.issn0263-6484
dc.identifier.issn1099-0844
dc.identifier.issue2en_US
dc.identifier.pmid15386528en_US
dc.identifier.scopus2-s2.0-14944378129en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage85en_US
dc.identifier.urihttps://doi.org/10.1002/cbf.1166
dc.identifier.urihttps://hdl.handle.net/20.500.12491/5745
dc.identifier.volume23en_US
dc.identifier.wosWOS:000227510800002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKükner, Aysel
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofCell Biochemistry And Functionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMelatoninen_US
dc.subjectCarbon Tetrachlorideen_US
dc.subjectNephrotoxicityen_US
dc.subjectUreaen_US
dc.subjectCreatinineen_US
dc.subjectHistopathologyen_US
dc.subjectLight Microscopyen_US
dc.titleReduction of carbon tetrachloride-induced nephropathy by melatonin administrationen_US
dc.typeArticleen_US

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