The important role of TMPRSS2 gene in covid-19 and prostate cancer: in silico approach

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dc.authorid0000-0002-0462-3171en_US
dc.authorid0000-0001-6509-4720en_US
dc.authorid0000-0003-1417-6915en_US
dc.authorid0000-0001-5288-6040en_US
dc.contributor.authorKalkanlı, Arif
dc.contributor.authorKırkık, Duygu
dc.contributor.authorBostancı, Emre
dc.contributor.authorTaş, Sevgi Kalkanlı
dc.date.accessioned2023-05-12T06:36:18Z
dc.date.available2023-05-12T06:36:18Z
dc.date.issued2021en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractSome studies have discovered a connection between prostate cancer and COVID-19. In this study, we evaluated the link between prostate cancer and COVID-19, contributing to elucidate the connection between TMPRSS2 and ACE2. We discovered 209 number of variants in TMPRSS2 gene, and 110 variants represent EA populations and 99 of them represent AA populations. Moreover, we found 23 suspected missense and 3 unknown variants. Then, linked genes to TMPRSS2 and ACE2 were found in our study. We investigated the expression level of TMPRSS2 and the results showed that it was very high in the prostate, colon, lung, kidney, and saliva-secreting gland. Also, the important role of the AR gene was revealed in addition to other oncogenes and tumor suppressor genes for prostate cancer by KEGG Pathway analysis. In conclusion, these results can highlight several molecular mechanisms of SARS-CoV-2, and also TMPRSS2, ACE2, and AR connection explains the high expression level of AR gene found in the male lung.en_US
dc.identifier.citationKalkanli, A., Kirkik, D., Bostanci, E., & Tas, S. K. (2021). The important role of TMPRSS2 Gene in covid-19 and prostate cancer: in silico approach. Brazilian Archives of Biology and Technology, 64.en_US
dc.identifier.doi10.1590/1678-4324-2021200785
dc.identifier.issn1516-8913
dc.identifier.issn1678-4324
dc.identifier.scopus2-s2.0-85121543810en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttp://dx.doi.org/10.1590/1678-4324-2021200785
dc.identifier.urihttps://hdl.handle.net/20.500.12491/10869
dc.identifier.volume64en_US
dc.identifier.wosWOS:000723173700001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorBostancı, Emre
dc.language.isoenen_US
dc.publisherINST TECNOLOGIA PARANAen_US
dc.relation.ispartofBrazilian Archives Of Biology And Technologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCOVID-19en_US
dc.subjectACE2en_US
dc.subjectProstate Canceren_US
dc.subjectARen_US
dc.titleThe important role of TMPRSS2 gene in covid-19 and prostate cancer: in silico approachen_US
dc.typeArticleen_US

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