The important role of TMPRSS2 gene in covid-19 and prostate cancer: in silico approach
Yükleniyor...
Dosyalar
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
INST TECNOLOGIA PARANA
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Some studies have discovered a connection between prostate cancer and COVID-19. In this study,
we evaluated the link between prostate cancer and COVID-19, contributing to elucidate the connection
between TMPRSS2 and ACE2. We discovered 209 number of variants in TMPRSS2 gene, and 110 variants
represent EA populations and 99 of them represent AA populations. Moreover, we found 23 suspected
missense and 3 unknown variants. Then, linked genes to TMPRSS2 and ACE2 were found in our study. We
investigated the expression level of TMPRSS2 and the results showed that it was very high in the prostate,
colon, lung, kidney, and saliva-secreting gland. Also, the important role of the AR gene was revealed in
addition to other oncogenes and tumor suppressor genes for prostate cancer by KEGG Pathway analysis. In
conclusion, these results can highlight several molecular mechanisms of SARS-CoV-2, and also TMPRSS2,
ACE2, and AR connection explains the high expression level of AR gene found in the male lung.
Açıklama
Anahtar Kelimeler
COVID-19, ACE2, Prostate Cancer, AR
Kaynak
Brazilian Archives Of Biology And Technology
WoS Q Değeri
Q4
Scopus Q Değeri
Q2
Cilt
64
Sayı
Künye
Kalkanli, A., Kirkik, D., Bostanci, E., & Tas, S. K. (2021). The important role of TMPRSS2 Gene in covid-19 and prostate cancer: in silico approach. Brazilian Archives of Biology and Technology, 64.
