Nitrite/Nitrate and malondialdehyde levels in nasal polyp
Yükleniyor...
Dosyalar
Tarih
2008
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
CMB Association
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
The aim of this study was to examine the pathophysiological role of NO (nitric oxide) and MDA (malondialdehyde) in tissue in patients with nasal polyposis. We measured nitrite/nitrate (Nitrite/Nitrate; NO(2)(-)/NO(3)(-)) and MDA in tissue and plasma of NP patients (n=20) and controls (n=20). MDA level expressed as the concentration of substances reacting to thiobarbituric acid and production of NO (concentration of nitrite/nitrate in plasma) by the Griess reaction were determined. The level of NO(2)(-) and NO(3)(-) in tissue are higher than that of the normal tissue (p<0.05). The level of MDA in tissue are higher than that of the normal tissue (p<0.05). The level of NO(2)(-) and NO(3)(-) in plasma of two groups are similar (p>0.05). The level of MDA in plasma is higher than that in the normal controls (p<0.05). The change in NO(2)(-)/NO(3)(-) and MDA levels of nasal polyp patients was demonstrated. Further studies are required concerning the significance of changes in lipid peroxidation and nitrite levels in pathogenesis of nasal polyp.
Açıklama
Anahtar Kelimeler
Inflammation, Oxidative Stress, Malondialdehyde, Nitric Oxide, Nasal Polyposis
Kaynak
Cellular And Molecular Biology
WoS Q Değeri
Q4
Scopus Q Değeri
Q4
Cilt
54
