Nitrite/Nitrate and malondialdehyde levels in nasal polyp

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Küçük Resim

Tarih

2008

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

CMB Association

Erişim Hakkı

info:eu-repo/semantics/openAccess

Özet

The aim of this study was to examine the pathophysiological role of NO (nitric oxide) and MDA (malondialdehyde) in tissue in patients with nasal polyposis. We measured nitrite/nitrate (Nitrite/Nitrate; NO(2)(-)/NO(3)(-)) and MDA in tissue and plasma of NP patients (n=20) and controls (n=20). MDA level expressed as the concentration of substances reacting to thiobarbituric acid and production of NO (concentration of nitrite/nitrate in plasma) by the Griess reaction were determined. The level of NO(2)(-) and NO(3)(-) in tissue are higher than that of the normal tissue (p<0.05). The level of MDA in tissue are higher than that of the normal tissue (p<0.05). The level of NO(2)(-) and NO(3)(-) in plasma of two groups are similar (p>0.05). The level of MDA in plasma is higher than that in the normal controls (p<0.05). The change in NO(2)(-)/NO(3)(-) and MDA levels of nasal polyp patients was demonstrated. Further studies are required concerning the significance of changes in lipid peroxidation and nitrite levels in pathogenesis of nasal polyp.

Açıklama

Anahtar Kelimeler

Inflammation, Oxidative Stress, Malondialdehyde, Nitric Oxide, Nasal Polyposis

Kaynak

Cellular And Molecular Biology

WoS Q Değeri

Q4

Scopus Q Değeri

Q4

Cilt

54

Sayı

Künye