Does serum neutrophil gelatinase-associated lipocalin biomarker detect the early deterioration in renal functions in patients with insulin-dependent diabetes mellitus undergoing coronary artery bypass graft surgery?

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dc.authorid0000-0002-1487-7407en_US
dc.authorid0000-0002-1276-8549en_US
dc.authorid0000-0002-4227-9420
dc.contributor.authorBuğra, Onursal
dc.contributor.authorBaysal, Ayşe
dc.contributor.authorFedakar, Ali
dc.contributor.authorErdem, Kemalettin
dc.contributor.authorSunar, Hasan
dc.contributor.authorDağlar, Bahadır
dc.date.accessioned2021-06-23T19:36:56Z
dc.date.available2021-06-23T19:36:56Z
dc.date.issued2014
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground: This study aims to investigate the effects of serum neutrophil gelatinase-associated lipocalin (NGAL) on early detection of renal injury in patients with diabetes mellitus undergoing coronary artery bypass grafting (CABG). Methods: Between January 2010 and December 2011, 113 patients who underwent an isolated elective CABG with cardiopulmonary bypass (CPB) in our clinic were divided into two groups. Routine renal functions and serum NGAL were measured in group 1 (33 males, 20 females; mean age 63.6 +/- 7.2 years; range 50 to 73 years), while only routine renal functions were measured in group 2 (40 males, 20 females; mean age 64.6 +/- 8.3 years; range 49 to 76 years). Parameters were collected at 2, 24 and 72 hours after CPB. Renal injury was defined as serum creatinine level exceeding 1.2 mg/dL. Based on this definition, study groups were divided into subgroups. A possible correlation between serum NGAL values and development of acute renal failure in the early postoperative period was investigated in between the groups and subgroups. Results: All patients with renal injury according to the measurements of serum NGAL values at two hours following CPB had renal injury based on serum creatinine measurements at 72 hours of CPB. All patients without renal injury based on serum creatinine measurements at 72 hours of CPB did not have renal injury based on NGAL measurements at two hours of CPB. Serum NGAL values at two hours after CPB appeared to be determinants in predicting the development of acute renal injury at 72 hours. Conclusion: Elevated levels of serum NGAL at two hours after CPB are strong indicators of renal injury and may be an early warning on the measures to be taken. Serum creatinine levels are usually increased in the late stage and, therefore, renal injury can not be prevented when detected.en_US
dc.identifier.doi10.5606/tgkdc.dergisi.2014.7780
dc.identifier.endpage70en_US
dc.identifier.issn1301-5680
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-84897696094en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage63en_US
dc.identifier.urihttps://doi.org/10.5606/tgkdc.dergisi.2014.7780
dc.identifier.urihttps://hdl.handle.net/20.500.12491/8080
dc.identifier.volume22en_US
dc.identifier.wosWOS:000330199000011en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorBuğra, Onursal
dc.institutionauthorErdem, Kemalettin
dc.institutionauthorDağlar, Bahadır
dc.language.isotren_US
dc.publisherBaycinar Medical Publ.en_US
dc.publisherBayçınar Tibbı Yayıncılık
dc.relation.ispartofTürk Göğüs Kalp Damar Cerrahisi Dergisien_US
dc.relation.ispartofTurkish Journal Of Thoracic And Cardiovascular Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcute Renal Failureen_US
dc.subjectElective Coronary Artery Bypass Graftingen_US
dc.subjectNeutrophil Gelatinase-associated Lipocalinen_US
dc.subjectSerum Creatinineen_US
dc.subjectAkut Böbrek Yetmezliği
dc.subjectElektif Koroner Arter Greftleme
dc.subjectNötrofil Jelatinaz İlişkili Lipokalin
dc.subjectSerum Kreatinin
dc.titleDoes serum neutrophil gelatinase-associated lipocalin biomarker detect the early deterioration in renal functions in patients with insulin-dependent diabetes mellitus undergoing coronary artery bypass graft surgery?en_US
dc.title.alternativeİnsüline bağlı diyabeti olan hastalarda gerçekleştirilen koroner arter baypas greft cerrahisinde serum nötrofil jelatinaz ilişkili lipokalin belirteci böbrek fonksiyonlarındaki bozulmayı erken dönemde belirler mi?en_US
dc.typeArticleen_US

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