Does serum neutrophil gelatinase-associated lipocalin biomarker detect the early deterioration in renal functions in patients with insulin-dependent diabetes mellitus undergoing coronary artery bypass graft surgery?
Yükleniyor...
Tarih
2014
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Baycinar Medical Publ.
Bayçınar Tibbı Yayıncılık
Bayçınar Tibbı Yayıncılık
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background: This study aims to investigate the effects of serum neutrophil gelatinase-associated lipocalin (NGAL) on early detection of renal injury in patients with diabetes mellitus undergoing coronary artery bypass grafting (CABG). Methods: Between January 2010 and December 2011, 113 patients who underwent an isolated elective CABG with cardiopulmonary bypass (CPB) in our clinic were divided into two groups. Routine renal functions and serum NGAL were measured in group 1 (33 males, 20 females; mean age 63.6 +/- 7.2 years; range 50 to 73 years), while only routine renal functions were measured in group 2 (40 males, 20 females; mean age 64.6 +/- 8.3 years; range 49 to 76 years). Parameters were collected at 2, 24 and 72 hours after CPB. Renal injury was defined as serum creatinine level exceeding 1.2 mg/dL. Based on this definition, study groups were divided into subgroups. A possible correlation between serum NGAL values and development of acute renal failure in the early postoperative period was investigated in between the groups and subgroups. Results: All patients with renal injury according to the measurements of serum NGAL values at two hours following CPB had renal injury based on serum creatinine measurements at 72 hours of CPB. All patients without renal injury based on serum creatinine measurements at 72 hours of CPB did not have renal injury based on NGAL measurements at two hours of CPB. Serum NGAL values at two hours after CPB appeared to be determinants in predicting the development of acute renal injury at 72 hours. Conclusion: Elevated levels of serum NGAL at two hours after CPB are strong indicators of renal injury and may be an early warning on the measures to be taken. Serum creatinine levels are usually increased in the late stage and, therefore, renal injury can not be prevented when detected.
Açıklama
Anahtar Kelimeler
Acute Renal Failure, Elective Coronary Artery Bypass Grafting, Neutrophil Gelatinase-associated Lipocalin, Serum Creatinine, Akut Böbrek Yetmezliği, Elektif Koroner Arter Greftleme, Nötrofil Jelatinaz İlişkili Lipokalin, Serum Kreatinin
Kaynak
Türk Göğüs Kalp Damar Cerrahisi Dergisi
Turkish Journal Of Thoracic And Cardiovascular Surgery
Turkish Journal Of Thoracic And Cardiovascular Surgery
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
22
Sayı
1
