Effects of Ibuprofen on Orthotopic Glioma Model in Rats

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dc.authoridBilir, Ayhan/0009-0009-9399-5927
dc.contributor.authorDagistan, Yasar
dc.contributor.authorKaraca, Ismail
dc.contributor.authorBozkurt, Erol Rustu
dc.contributor.authorBilir, Ayhan
dc.date.accessioned2024-09-25T19:59:56Z
dc.date.available2024-09-25T19:59:56Z
dc.date.issued2012
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractObjective: To determine the effects of ibuprofen (Ibp) on the vessel proliferation and necrosis in a rat glioma model. Study Design: Experimental, randomized interventional trial. Place and Duration of Study: 1st Neurosurgery Clinic in Bakirkoy Mental Diseases Hospital, Bakirkoy, Istanbul, Turkey, in the year 2010. Methodology: After stereotactic injection of C6/LacZ rat glioma cells into the Wistar rats brain, the rats were randomly assigned to two treatment groups (group 1, control; group 2, Ibp treatment). Rats were sacrificed 18 days after treatment, and number of intra-/peri-tumoural vessels, microendothelial proliferations, immunohistochemistry and necrotic area were evaluated. Results: Ibp treatment significantly decreased tumour tissue, intratumoral vessel number and total tumour area level. The level of Ki67 was significantly decreased in the tumour tissue of group 2. Additionally, the total necrotic area / total tumour volume (%) was significantly less in the tumour tissue of the ibuprofen-treated rats compared to the controls. Conclusion: The data show that the Ibp produced an important reduction in glioma tumour cell proliferation in the rat model.en_US
dc.identifier.endpage693en_US
dc.identifier.issn1022-386X
dc.identifier.issue11en_US
dc.identifier.pmid23146847en_US
dc.identifier.startpage690en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/13975
dc.identifier.volume22en_US
dc.identifier.wosWOS:000311869300004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherColl Physicians & Surgeons Pakistanen_US
dc.relation.ispartofJcpsp-Journal of The College of Physicians And Surgeons Pakistanen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzYK_20240925en_US
dc.subjectRaten_US
dc.subjectOrthotopic gliomaen_US
dc.subjectNon-steroidal anti-inflammatory drugsen_US
dc.subjectIbuprofenen_US
dc.subjectStereotactic injectionen_US
dc.subjectC-6 glioma cell lineen_US
dc.titleEffects of Ibuprofen on Orthotopic Glioma Model in Ratsen_US
dc.typeArticleen_US

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