Effect of thimerosal on arrhythmia induced by coronary ligation - the involvement of ATP-dependent potassium channels

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dc.authorid0000-0001-5073-0691en_US
dc.authorid0000-0002-7527-4634
dc.authorid0000-0003-1730-6463
dc.contributor.authorBozdoğan, Ömer
dc.contributor.authorGonca, Ersöz
dc.contributor.authorNebigil, Melih
dc.contributor.authorTiryaki, Eylem Suveren
dc.date.accessioned2021-06-23T19:18:20Z
dc.date.available2021-06-23T19:18:20Z
dc.date.issued2005
dc.departmentBAİBÜ, Fen Edebiyat Fakültesi, Biyoloji Bölümüen_US
dc.description.abstractThiol-modifying agents induce the release of nitric oxide (NO) from endothelial epithelium and the release of reactive oxygen free radicals in the vascular system. Moreover, thiol groups are essential for the functioning of the ATP dependent potassium channel (KATP). The effects of thiol-modifying agents and their molecular mechanisms on arrhythmia have not been widely studied. In this study, we investigated the effect of the hydrophilic SH-group-oxidizing substance thimerosal on the arrhythmia induced by reperfusion/ischemia after coronary artery ligation in rats. We studied the possible involvement of the K-ATP and NOS on the effect of thimerosal. Thimerosal pretreatment (3, 30 mg/kg dose iv. 10 minutes before coronary occlusion) significantly decreased the length of total arrhythmia, ventricular tachycardia, and the arrhythmia score. This effect of thimerosal was reversed by the K-ATP opener pinacidil but not by the K-ATP blocker glibenclamide. The inhibition of iNOS by L-NAME did not alter the antiarrhythmic effect of thimerosal. These data clearly suggest that the antiarrhythmic effect of thimerosal is dependent upon the blockage of K-ATP.en_US
dc.identifier.doi10.1536/ihj.46.711
dc.identifier.endpage721en_US
dc.identifier.issn1349-2365
dc.identifier.issue4en_US
dc.identifier.pmid16157962en_US
dc.identifier.scopus2-s2.0-33644878472en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage711en_US
dc.identifier.urihttps://doi.org/10.1536/ihj.46.711
dc.identifier.urihttps://hdl.handle.net/20.500.12491/5703
dc.identifier.volume46en_US
dc.identifier.wosWOS:000232575300015en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBozdoğan, Ömer
dc.institutionauthorGonca, Ersöz
dc.institutionauthorNebigil, Melih
dc.institutionauthorTiryaki, Eylem Suveren
dc.language.isoenen_US
dc.publisherInternational Heart Journal Associationen_US
dc.relation.ispartofInternational Heart Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIschemia and Reperfusionen_US
dc.subjectArrhythmiaen_US
dc.subjectATP-dependent Potassium Channel Blockeren_US
dc.subjectThimerosalen_US
dc.titleEffect of thimerosal on arrhythmia induced by coronary ligation - the involvement of ATP-dependent potassium channelsen_US
dc.typeArticleen_US

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