Efficacy and safety of direct-acting antivirals in elderly patients with chronic hepatitis C: A nationwide real-life, observational, multicenter study from Turkey

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dc.authorid0000-0002-8163-1386en_US
dc.authorid0000-0002-5315-122Xen_US
dc.authorid0000-0003-1148-2247en_US
dc.authorid0000-0001-6382-2229en_US
dc.authorid0000-0002-9400-0997en_US
dc.contributor.authorÖnlen, Yusuf
dc.contributor.authorBal, Tayibe
dc.contributor.authorÇabalak, Mehmet
dc.contributor.authorÇuvalcı, Nefise Öztoprak
dc.contributor.authorSarı, Nagehan Didem
dc.contributor.authorCan, Güray
dc.contributor.authorSırmatel, Fatma
dc.date.accessioned2023-09-11T07:58:19Z
dc.date.available2023-09-11T07:58:19Z
dc.date.issued2022en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground: The number and proportion of elderly patients living with chronic hepatitis C are expected to increase in the coming years. We aimed to compare the real-world efficacy and safety of direct-acting antiviral treatment in elderly and younger Turkish adults infected with chronic hepatitis C. Methods: In this multicenter prospective study, 2629 eligible chronic hepatitis C patients treated with direct-acting antivirals between April 2017 and December 2019 from 37 Turkish referral centers were divided into 2 age groups: elderly (>= 65 years) and younger adults (<65 years) and their safety was compared between 2 groups in evaluable population. Then, by matching the 2 age groups for demographics and pretreatment risk factors for a non-sustained virological response, a total of 1516 patients (758 in each group) and 1244 patients (622 in each group) from the modified evaluable population and per-protocol population were included in the efficacy analysis and the efficacy was compared between age groups. Results: The sustained virological response in the chronic hepatitis C patients was not affected by the age and the presence of cirrhosis both in the modified evaluable population and per-protocol population (P =.879, P =.508 for modified evaluable population and P =.058, P =.788 for per-protocol population, respectively). The results of the per-protocol analysis revealed that male gender, patients who had a prior history of hepatocellular carcinoma, patients infected with non-genotype 1 hepatitis C virus, and patients treated with sofosbuvir + ribavirin had a significantly lower sustained virological response 12 rates (P <.001, P =.047, P =.013, and P =.025, respectively). Conclusion: Direct-acting antivirals can be safely used to treat Turkish elderly chronic hepatitis C patients with similar favorable efficacy and safety as that in younger adults.en_US
dc.identifier.citationÖnlen, Y., Bal, T., Çabalak, M., Öztoprak, N. Ç., Sarı, N. D., Kurtaran, B., ... & Tabak, F. (2022). Efficacy and Safety of Direct-Acting Antivirals in Elderly Patients with Chronic Hepatitis C: A Nationwide Real-Life, Observational, Multicenter Study from Turkey. The Turkish Journal of Gastroenterology, 33(10), 862.en_US
dc.identifier.doi10.5152/tjg.2022.21271
dc.identifier.endpage873en_US
dc.identifier.issue10en_US
dc.identifier.pmid35946896en_US
dc.identifier.scopus2-s2.0-85139571415en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage862en_US
dc.identifier.trdizinid1134402en_US
dc.identifier.urihttp://dx.doi.org/10.5152/tjg.2022.21271
dc.identifier.urihttps://hdl.handle.net/20.500.12491/11688
dc.identifier.volume33en_US
dc.identifier.wosWOS:000955590200007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorCan, Güray
dc.institutionauthorSırmatel, Fatma
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Gastroenterologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAgeen_US
dc.subjectChronic Hepatitis Cen_US
dc.subjectDirect-Acting Antiviral Agentsen_US
dc.subjectSofosbuvir Plus Ribavirinen_US
dc.subjectHCV Infectionen_US
dc.subjectHepatocellular-Carcinomaen_US
dc.titleEfficacy and safety of direct-acting antivirals in elderly patients with chronic hepatitis C: A nationwide real-life, observational, multicenter study from Turkeyen_US
dc.typeArticleen_US

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