Could thrombocyte parameters be an inflammatory marker in the brucellosis?
Yükleniyor...
Tarih
2013
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Medical Association of Zenica-Doboj Canton
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Aim To investigate links between platelet parameters mean platelet volume (MPV), platelet count (PC), platelet distribution width
(PDW), platelet mass (PM) and brucella tube agglutination titers
(BSTAT) in patients with brucellosis. Initially, PC, MPV, PM and
PDW calculations were compared between periods before and
after treatment. The correlation between inlammation markers
(erythrocyte sedimentation rate, ESR, white blood cell count,
WBC, and C reactive protein, CRP) and platelet parameters was
subsequently investigated.
Methods This self-controlled study included 40 patients who had
positive BSTAT at least at a titer of 1/160. Platelet parameters and
inlammation values (CRP, ESR) at the time of positive BSTAT at
least at a titer of 1/160 (pre-treatment) were compared with control
of the same parameters at the time when BSTAT became negative
or when the titers reduced 4 folds (post-treatment).
Results Mean platelet volume values (7.90+1.96) were signiicantly elevated in post treatment period when compared to pre
treatment (7.58+1.96), (p= 0.023). Post treatment CRP, ESR and
PC were signiicantly reduced when compared to pretreatment values (p=0.000, p=0.000 and p=0.025, respectively). In the pretreatment period, a direct correlation between ESR and PC values
(r=0.036, p=0.025), and inverse correlations between ESR with
MPV (r=-0.337, p=0.038) was found. A dependent predictive factor in multivariate logistic regression analysis for BSTAT was not
found.
Conclusion We suggest that PC and MPV may be inlammatory
markers in brucellosis.
Açıklama
Anahtar Kelimeler
Acute-Phase Reaction, Blood Platelets, Inlammation
Kaynak
Medicinski Glasnik
WoS Q Değeri
Scopus Q Değeri
Q4
Cilt
10
Sayı
1
