Does methylene blue reduce adhesion during the healing process after tendon repair?

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dc.authorid0000-0003-0710-6978
dc.authorid0000-0003-2153-7774
dc.authorid0000-0001-8058-1690
dc.authorid0000-0002-8973-2050
dc.authorid0000-0001-6768-1275
dc.authorid0000-0002-7213-5647
dc.authorid0000-0003-0700-6512
dc.contributor.authorBoz, Mehmet
dc.contributor.authorÇakıcı, Hüsamettin
dc.contributor.authorPakdil, Murat
dc.contributor.authorŞahin, Abdullah Alper
dc.contributor.authorDüzcü, Selma Erdoğan
dc.contributor.authorBala, Mehmet Murat
dc.contributor.authorÇelik, Metin
dc.date.accessioned2021-06-23T19:54:48Z
dc.date.available2021-06-23T19:54:48Z
dc.date.issued2020
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractObjectives: This study aims to biomechanically and histopathologically investigate the effects of methylene blue (MB) on preventing postoperative adhesion in chickens undergoing full - thickness flexor tendon incision. Materials and methods: This study was performed between June 2017 and June 2018 on Hubbard JA 57 type chickens (age, 6 months; weight, 2.2?0.3 kg). Sixty-four tendons were studied in 32 chickens, including 16 in the control group and 16 in the experimental group. The second and third finger flexor digitorum profundus tendons of the left foot of each chicken were repaired primarily after a full -thickness incision approximately 1 cm proximal to the distal adhesion area. In the control (n=32) and experimental groups (n=32), 0.25 mL of normal saline and 0.25 mL of 1% MB solutions were applied locally to the surgical site, respectively. The operated limb was immobilized using a circular cast. 16 chickens were randomly selected in each group and examined at the fourth week, and the remaining 16 chickens were examined at the sixth week. Thirty-two of these tendons were evaluated using the Tang histopathological adhesion classification system, and the other 32 were evaluated with a biomechanical pull system. Results: Adhesion was found to be less in the experimental group compared to the control group at the end of the fourth and sixth weeks both histopathologically and biomechanically. Furthermore, adhesion was significantly less in the experimental group at the end of the sixth week compared to the fourth week both histopathologically and biomechanically. Conclusion: Histopathological and biomechanical results show that MB, which has anti-inflammatory, antiseptic, antimicrobial and antioxidant effects, reduces adhesion during the healing process after tendon repair. We think that local MB application, particularly in surgeries performed after this type of injury, will be beneficial on early rehabilitation and functional results.en_US
dc.identifier.doi10.5606/ehc.2020.74405
dc.identifier.endpage254en_US
dc.identifier.issn2687-4784
dc.identifier.issn2687-4792
dc.identifier.issue2en_US
dc.identifier.pmid32584721en_US
dc.identifier.scopus2-s2.0-85089482339en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage246en_US
dc.identifier.trdizinid407659en_US
dc.identifier.urihttps://doi.org/10.5606/ehc.2020.74405
dc.identifier.urihttps://hdl.handle.net/20.500.12491/10652
dc.identifier.volume31en_US
dc.identifier.wosWOS:000545984600012en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÇakıcı, Hüsamettin
dc.institutionauthorPakdil, Murat
dc.institutionauthorDüzcü, Selma Erdoğan
dc.language.isoenen_US
dc.publisherTurkish Joint Diseases Foundationen_US
dc.relation.ispartofJoint Diseases And Related Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectChicken Flexor Tendonen_US
dc.subjectFlexor Tendon Adhesionen_US
dc.subjectMethylene Blueen_US
dc.subjectTendon Healingen_US
dc.titleDoes methylene blue reduce adhesion during the healing process after tendon repair?en_US
dc.typeArticleen_US

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