Netrin-1 and its receptor Unc5b as markers of periodontal disease

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dc.authorid0000-0001-9848-0927en_US
dc.authorid0000-0002-6558-3775en_US
dc.contributor.authorGünpınar, Şadiye
dc.contributor.authorMeracı, Bilge
dc.contributor.authorDündar, Niyazi
dc.date.accessioned2021-06-23T19:54:59Z
dc.date.available2021-06-23T19:54:59Z
dc.date.issued2020
dc.departmentBAİBÜ, Diş Hekimliği Fakültesi, Periodontoloji Ana Bilim Dalıen_US
dc.description.abstractObjectives The aim of this present study was to evaluate the levels of Netrin-1 and Unc5b in periodontal health and disease. Background Netrin-1, acting via its receptor UNC5b, regulates the inflammatory response and takes apart in bone destructive diseases. Methods Samples of gingival crevicular fluid (GCF), whole saliva, and serum were taken from systemically healthy, nonsmoking 20 periodontitis , 20 gingivitis patients, and 20 periodontally healthy subjects at baseline and 4 weeks after nonsurgical periodontal treatment (NSPT). Whole-mouth and site-specific clinical periodontal parameters were recorded. Netrin-1 and Unc5b levels were measured by enzyme-linked immunosorbent assay. Data were analyzed by nonparametric tests. Results Total amount of Netrin-1 in GCF was significantly higher in periodontitis than the others, and the levels were significantly reduced after NSPT. Salivary and serum concentrations of Netrin-1 were significantly different among the study groups (P = .000), and NSPT significantly increased the concentration levels of both salivary and serum Netrin-1 (P < .05). Healthy subjects had significantly lower GCF (P = .001) and conversely, higher salivary and serum levels of Unc5b than the other groups (P = .002). The GCF levels of Unc5b were significantly reduced (P < .01), and conversely, serum concentrations were significantly increased after NSPT (P < .05). GCF Netrin-1 and Unc5b total amounts were positively correlated with clinical parameters (P P < .05) whereas salivary Netrin-1 and Unc5b concentrations were negatively correlated with clinical parameters (P P < .05). Conclusions The results of this study indicate that Netrin-1 and its receptor Unc5b may have essential roles in periodontal inflammation and those can be assumed as useful therapeutic agent to control inflammation and periodontal breakdown.en_US
dc.identifier.doi10.1111/jre.12712
dc.identifier.endpage276en_US
dc.identifier.issn0022-3484
dc.identifier.issn1600-0765
dc.identifier.issue2en_US
dc.identifier.pmid31769036en_US
dc.identifier.scopus2-s2.0-85075731366en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage267en_US
dc.identifier.urihttps://doi.org/10.1111/jre.12712
dc.identifier.urihttps://hdl.handle.net/20.500.12491/10699
dc.identifier.volume55en_US
dc.identifier.wosWOS:000498401300001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorGünpınar, Şadiye
dc.institutionauthorMeracı, Bilge
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal Of Periodontal Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCellular Immunologyen_US
dc.subjectGingival Crevice Fluiden_US
dc.subjectInflammationen_US
dc.subjectMacrophagesen_US
dc.subjectNonsurgical Periodontal Therapyen_US
dc.subjectPeriodontal Diseaseen_US
dc.titleNetrin-1 and its receptor Unc5b as markers of periodontal diseaseen_US
dc.typeArticleen_US

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