Mast cells: Target and source of neuropeptides

Basit Öğe Kaydı
dc.authorid0000-0001-5912-9392
dc.contributor.authorTöre, Fatma
dc.contributor.authorTuncel, Neşe
dc.date.accessioned2021-06-23T19:26:06Z
dc.date.available2021-06-23T19:26:06Z
dc.date.issued2009
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractMast cells, originating from bone marrow pluripotential cells are generally populated near to strategic locations of mammalian body. They store a wide variety of biologically active molecules in their granules and also can de novo synthesize an additional spectrum of mediators, depending on their microenvironment, phenotype and status. Mast cells have numerous receptors that can trigger a wide spectrum of cellular responses, some of them which can be preprogrammed against specific pathogens. Mast cells secrete mediators, go under total degranulation, or degranulate only some of the specific granules with required content according to the environmental conditions, pathogens or signaling molecules binding to their receptors. Mast cells are functionally multi faceted cells. A single cell can behave such as an immune cell, an endocrine cell and even as a sensorial neuron. In this context, mast cells can significantly influence inflammation, tissue remodeling, host defense and homeostasis. Specifically the mast cells proximal to nerve fibers, contain, secrete and respond to, several neuropeptides, suggesting many potential functions for mast cells in health and disease. Mast cells are target cells for neuropeptides and, they have distinct profiles of responsiveness to these molecules. This extends the flexibility of neurogenic signaling pathways via reciprocity. Those neuropeptides have direct and indirect effects on mast cells such as inducing or suppression of degranulation, triggering, modulation or amplification of mediator content and release. The exploration of interactions of mast cells and neurons is a promising field of study which may bring treatments to several diseases. Since mast cells seem to form the major link between neurons and inflammation via neuropeptides, mast cell and mast cell mediator connection may lead to a better understanding of the autocrine, paracrine, and neuro-immune-endocrine systems in physiology and physiopathology. Therefore, mast cell manipulator drug designs, capable of granular content modulation, with effects on, selective mediator release, activity and, ablation of mast cells, would be very beneficial for the treatment of various diseases that mast cells may be involved in.en_US
dc.identifier.doi10.2174/138161209789105036
dc.identifier.endpage3445en_US
dc.identifier.issn1381-6128
dc.identifier.issn1873-4286
dc.identifier.issue29en_US
dc.identifier.pmid19860689en_US
dc.identifier.scopus2-s2.0-70449389370en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage3433en_US
dc.identifier.urihttps://doi.org/10.2174/138161209789105036
dc.identifier.urihttps://hdl.handle.net/20.500.12491/6414
dc.identifier.volume15en_US
dc.identifier.wosWOS:000271384700006en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorTöre, Fatma
dc.language.isoenen_US
dc.publisherBentham Science Publ Ltden_US
dc.relation.ispartofCurrent Pharmaceutical Designen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMast Cellen_US
dc.subjectSubstance Pen_US
dc.subjectCalcitonine Gene Related Peptideen_US
dc.subjectGalaninen_US
dc.subjectNeuromedin Uen_US
dc.subjectNeurotensinen_US
dc.subjectUrocortinen_US
dc.subjectVasoactive Intestinal Peptideen_US
dc.titleMast cells: Target and source of neuropeptidesen_US
dc.typeReview Articleen_US

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