The effects of local and systemic administration of proline on wound healing in rats

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dc.authorid0000-0002-4326-2102en_US
dc.authorid0000-0002-9698-5080en_US
dc.authorid0000-0002-0407-9655
dc.authorid0000-0002-9698-5080
dc.authorid0000-0002-6838-7454
dc.authorid0000-0001-8076-7911
dc.authorid0000-0003-2356-1452
dc.contributor.authorAydın, Hüsnü
dc.contributor.authorTatar, Cihad
dc.contributor.authorSavaş, Osman Anıl
dc.contributor.authorKarşıdağ, Tamer
dc.contributor.authorÖzer, Bahri
dc.contributor.authorDursun, Nevra
dc.contributor.authorBekem, Aylin
dc.date.accessioned2021-06-23T19:51:07Z
dc.date.available2021-06-23T19:51:07Z
dc.date.issued2019
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractPurpose: Wound healing consists of a sequence of complex molecular and cellular events. Collagen is composed mainly of proline and hydroxyproline. Proline and hydroxyproline constitute 1/3 of the amino acids in collagen, which makes up approximately 30% of the proteins within the body. The hydroxylation of proline found in collagen determines the stability of the triple helical structure of collagen. In this study, we examined the effects of local and systemic administration of proline on wound healing. Materials and Methods: 24 female Sprague-Dawley rats were used in the study and divided into three groups. Group 1: The defect created in the backs of the subjects was left to secondary healing. Group 2: 200 mu l proline per day was administered topically for 30 days on the defect in the backs of the subjects. Group 3: 200 mu l per day was administered intraperitoneally for 30 days on the defect in the backs of the subjects. Results: On day 21, there was a statistically significant difference between the groups in terms of the mean re-epithelialization score. On days 7 and 14, there was a statistically significant difference between the groups in terms of the mean granulation score. On days 7, 14, and 21, there was a statistically significant difference between the groups in terms of the mean collagen accumulation score. On day 30, there was a statistically significant difference between Groups 1 and 3 in terms of the mean E-mode score on mechanical tensile test. Conclusion: Our study confirmed that proline has positive effects on wound healing. However, it revealed that systemic administration of proline is more effective than local administration of proline.en_US
dc.identifier.doi10.1080/08941939.2018.1441342
dc.identifier.endpage529en_US
dc.identifier.issn0894-1939
dc.identifier.issn1521-0553
dc.identifier.issue6en_US
dc.identifier.pmid29494267en_US
dc.identifier.scopus2-s2.0-85042908873en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage523en_US
dc.identifier.urihttps://doi.org/10.1080/08941939.2018.1441342
dc.identifier.urihttps://hdl.handle.net/20.500.12491/9928
dc.identifier.volume32en_US
dc.identifier.wosWOS:000534625200006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÖzer, Bahri
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofJournal Of Investigative Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMechanical Tensile Testen_US
dc.subjectProlineen_US
dc.subjectRaten_US
dc.subjectWound Healingen_US
dc.titleThe effects of local and systemic administration of proline on wound healing in ratsen_US
dc.typeArticleen_US

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