Is low-risk prostate cancer really low-risk? Consider factors affecting biochemical recurrence and tumour upgrade

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dc.authorid0000-0002-1454-5672en_US
dc.contributor.authorSöğütdelen, Emrullah
dc.contributor.authorÇıtamak, Burak
dc.date.accessioned2023-08-15T11:16:43Z
dc.date.available2023-08-15T11:16:43Z
dc.date.issued2023en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractObjective: To evaluate the demographics, preoperative or pathological factors, and findings of magnetic resonance imaging (MRI) to predict the factors affecting biochemical recurrence and tumour upgrade in low-risk prostate cancer. Study Design: A descriptive study. Methodology: The data of 135 patients, who underwent radical prostatectomy for low-risk prostate cancer according to prostate-specific antigen (PSA) level, biopsy result and clinical stage, were analysed. Preoperative clinicopathological factors, MRI findings, and the final pathological results were analysed. Prognostic factors affecting the biochemical recurrence in the follow-up and tumour upgrade in the final pathology according to the International Society of Urological Pathology (ISUP) were evaluated. Results: Mean age and preoperative PSA level were 61.37 +/- 5.53 (46-74) years and 6.74 +/- 1.97 (range 1.88-9.9) ng/dL, respectively. Multivariate analysis showed that the prostate volume and diameter of lesions were statistically significant in the patients with ISUP upgrade (p=0.006, p=0.025, respectively), and surgical margin positivity in the final pathology specimen was statistically significant for biochemical recurrence (p=0.016). Logistic regression analysis revealed that prostate volume and diameter of the lesion in MRI were independent predictors of ISUP score upgrade. Receiver operating characteristic (ROC) curve analysis showed that tumour size on the MRI had 49.4% sensitivity and 77.8% specificity at 10 mm (AUC:0.634, p=0.009 for predicting). Conclusion: Lower prostate volume, higher diameter of lesions in multiparametric MRI and surgical margin positivity were associated factors affecting the ISUP score upgrade and biochemical recurrence. Therefore, patients should be evaluated preoperatively and patient-based factors should be considered in the choice of a treatment plan.en_US
dc.identifier.citationSogutdelen, E., & Citamak, B. (2023). Is Low-risk Prostate Cancer Really Low-risk? Consider Factors Affecting Biochemical Recurrence and Tumour Upgrade. Journal of the College of Physicians and Surgeons--Pakistan: JCPSP, 33(2), 193-198.en_US
dc.identifier.doi10.29271/jcpsp.2023.02.193
dc.identifier.endpage198en_US
dc.identifier.issn1022-386X
dc.identifier.issn1681-7168
dc.identifier.issue2en_US
dc.identifier.pmid36797630en_US
dc.identifier.scopus2-s2.0-85148255759en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage193en_US
dc.identifier.urihttp://dx.doi.org/10.29271/jcpsp.2023.02.193
dc.identifier.urihttps://hdl.handle.net/20.500.12491/11530
dc.identifier.volume33en_US
dc.identifier.wosWOS:000964672800014en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorSöğütdelen, Emrullah
dc.language.isoenen_US
dc.publisherColl Physicians & Surgeons Pakistanen_US
dc.relation.ispartofJCPSP-Journal of the College of Physicians and Surgeons Pakistanen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectProstate Canceren_US
dc.subjectCancer Upgradeen_US
dc.subjectTumour Sizeen_US
dc.subjectPredicten_US
dc.subjectGleasonen_US
dc.subjectBiopsyen_US
dc.titleIs low-risk prostate cancer really low-risk? Consider factors affecting biochemical recurrence and tumour upgradeen_US
dc.typeArticleen_US

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