Monocyte lymphocyte ratio as a predictor of diabetic kidney injury in type 2 diabetes mellitus; The MADKID Study

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dc.authorid0000-0001-7306-5233en_US
dc.authorid0000-0003-3085-7964
dc.authorid0000-0001-7306-5233
dc.authorid0000-0002-4542-4064
dc.contributor.authorKoçak, Mehmet Zahid
dc.contributor.authorAktaş, Gülali
dc.contributor.authorDuman, Tuba Taslamacıoğlu
dc.contributor.authorAtak, Burçin Meryem
dc.contributor.authorKurtkulağı, Özge
dc.contributor.authorTekçe, Hikmet
dc.contributor.authorBilgin, Satılmış
dc.date.accessioned2021-06-23T19:54:02Z
dc.date.available2021-06-23T19:54:02Z
dc.date.issued2020
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractAims Inflammation is a cardinal pathogenetic mechanism in diabetic kidney injury (DKI). The detection of microalbuminuria (MA) is very important in preventing end-stage renal failure in diabetic subjects. A combination of high monocyte and low lymphocyte counts are used as a marker of inflammation. Monocyte to lymphocyte ratio (MLR) is considered as a marker in inflammatory diseases. We aimed to evaluate the MLR levels in diabetic subjects as a predictive marker in detecting MA. Methods A total of 212 patients with type 2 diabetes mellitus (T2DM) were included in the study. Patients with T2DM were divided into two groups as MA and normoalbuminuria (NA). MLR of the groups were compared. Results There were 72 patients in MA and 140 patients in NA group. MLR of the MA and NA groups were 0.247 (0.131-0.540) and 0.211 (0.052-0.390), respectively (p < 0.001). There was a statistically significant correlation between MLR and MA (r = 0.228, p = 0.001). In multivariate backward logistic regression analysis, MLR, fasting blood glucose, HbA1c and presence of comorbid clinical diseases were determined as independent predictors of DKI. Conclusions We suggest that MLR could serve as a predictive and effective marker for DKI in diabetic subjects due to its strong correlation with MA and inexpensive and readily available nature.en_US
dc.identifier.doi10.1007/s40200-020-00595-0
dc.identifier.endpage1002en_US
dc.identifier.issn2251-6581
dc.identifier.issue2en_US
dc.identifier.pmid33553019en_US
dc.identifier.scopus2-s2.0-85088802518en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage997en_US
dc.identifier.urihttps://doi.org/10.1007/s40200-020-00595-0
dc.identifier.urihttps://hdl.handle.net/20.500.12491/10392
dc.identifier.volume19en_US
dc.identifier.wosWOS:000556945200002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKoçak, Mehmet Zahid
dc.institutionauthorTekçe, Hikmet
dc.institutionauthorAktaş, Gülali
dc.institutionauthorAtak, Burçin Meryem
dc.institutionauthorBilgin, Satılmış
dc.institutionauthorKurtkulağı, Özge
dc.language.isoenen_US
dc.publisherSpringer International Publishing Agen_US
dc.relation.ispartofJournal Of Diabetes And Metabolic Disordersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMonocyte lymphocyte ratioen_US
dc.subjectMicroalbuminuriaen_US
dc.subjectDiabetic Kidney Injuryen_US
dc.subjectInflammationen_US
dc.subjectType 2 Diabetes Mellitusen_US
dc.subjectHbA1cen_US
dc.titleMonocyte lymphocyte ratio as a predictor of diabetic kidney injury in type 2 diabetes mellitus; The MADKID Studyen_US
dc.typeArticleen_US

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