Promising medicinal plant Inula viscosa L.: Antiproliferative, antioxidant, antibacterial and phenolic profiles

dc.authorid0000-0001-5306-8584en_US
dc.authorid0000-0001-5306-8584
dc.authorid0000-0001-5245-6294
dc.authorid0000-0002-7631-823X
dc.contributor.authorÖzkan, Erva
dc.contributor.authorKarakaş, Fatma Pehlivan
dc.contributor.authorYıldırım, Arzu Birinci
dc.contributor.authorTaş, İsa
dc.contributor.authorEker, İsmail
dc.contributor.authorYavuz, Muhsine Zeynep
dc.contributor.authorTürker, Arzu Uçar
dc.date.accessioned2021-06-23T19:50:59Z
dc.date.available2021-06-23T19:50:59Z
dc.date.issued2019
dc.departmentBAİBÜ, Fen Edebiyat Fakültesi, Biyoloji Bölümüen_US
dc.description.abstractIntroduction. Inula viscosa (L.) Aiton (sticky fleabane) is popular medicinal plant in the family Asteraceae. It has been used in traditional medicine in the treatment of cancer, diabetes, hypertension, bronchitis, tuberculosis, wounds, skin diseases, infertility, lung and gastro-duodenal disorders. Methods. Aim of this study was to evaluate in vitro antiproliferative, antioxidant and antibacterial activities of aqueous and methanol extracts of aerial parts of I. viscosa and their phenolic constituents. Antiproliferative activity was evaluated against human breast adenocarcinoma (MCF-7) and human brain cancer (T98-G) cell lines using MTT assay. Antioxidant activity was revealed by using 2,2-diphenyl-1-picrylhydrazil (DPPH) method. Total phenol and flavonoid were determined by using Folin-Ciocaltaeu and aluminum chloride (AlCl3) colorimetric method, respectively. The disc diffusion assay was used to screen for antibacterial activity against 10 bacteria. Phenolic constituents were detected by High Performance Liquid Chromatography-Diode-Array Detector (HPLC-DAD) via chosen ten phenolic molecules (gallic acid, caffeic acid, rutin, luteolin, kaempferol, rosmarinic acid, myricetin, quercetin, coumarin and apigenin). Results. Methanol extract of I. viscosa demonstrated better antiproliferative activity than aqueous extract against MCF-7 and T98-G cell lines. Strong DPPH radical scavenging activity was observed with both extracts. Total phenol and flavonoid content of methanol extract were twice as much as aqueous extract. Only Gram-positive bacteria (S. aureus, S. epidermidis and S. pyogenes) were inhibited by both extracts of I. viscosa. HPLC-DAD analysis of phenolic compounds revealed that I. viscosa was significant source of kaempferol. Conclusion: I. viscosa showed promising antibacterial, antioxidant and anticancer activities, and further studies should be conducted to isolate the active components.en_US
dc.identifier.doi10.23751/pn.v21i3.7186
dc.identifier.endpage661en_US
dc.identifier.issn1129-8723
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85072271199en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage652en_US
dc.identifier.urihttps://doi.org/10.23751/pn.v21i3.7186
dc.identifier.urihttps://hdl.handle.net/20.500.12491/9901
dc.identifier.volume21en_US
dc.identifier.wosWOS:000486665700022en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorÖzkan, Erva
dc.institutionauthorKarakaş, Fatma Pehlivan
dc.institutionauthorYıldırım, Arzu Birinci
dc.institutionauthorTaş, İsa
dc.institutionauthorEker, İsmail
dc.institutionauthorYavuz, Muhsine Zeynep
dc.institutionauthorTürker, Arzu Uçar
dc.language.isoenen_US
dc.publisherMattioli 1885en_US
dc.relation.ispartofProgress In Nutritionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAantibacterialen_US
dc.subjectAnticanceren_US
dc.subjectAntioxidanten_US
dc.subjectAntiproliferativeen_US
dc.subjectExtractionen_US
dc.subjectInula Viscosaen_US
dc.titlePromising medicinal plant Inula viscosa L.: Antiproliferative, antioxidant, antibacterial and phenolic profilesen_US
dc.typeArticleen_US

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