The preparation of ciprofloxacin hydrochloride-loaded chitosan and pectin microspheres - their evaluation in an animal osteomyelitis model

dc.authorid0000-0001-7069-0623en_US
dc.authorid0000-0002-0486-2252en_US
dc.authorid0000-0002-7426-0740
dc.authorid0000-0001-6973-473X
dc.authorid0000-0001-9893-6330
dc.authorid0000-0002-9110-3704
dc.contributor.authorOrhan, Zafer
dc.contributor.authorCevher, Erdal
dc.contributor.authorMülazımoğlu, Lütfiye
dc.contributor.authorGürcan, Duygu
dc.contributor.authorAlper, Murat
dc.contributor.authorAraman, Ahmet
dc.contributor.authorÖzsoy, Yıldız
dc.date.accessioned2021-06-23T19:19:23Z
dc.date.available2021-06-23T19:19:23Z
dc.date.issued2006
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractCiprofloxacin hydrochloride-loaded microspheres were prepared by a spray-drying method using pectin and chitosan. The effects of different polymers and drug ratios were investigated. The most appropriate carriers were selected by in vitro testing. A rat methicillin-resistant Staphylococcus aureus osteomyelitis model was used to evaluate the effects of the loaded microspheres. The drug was released rapidly from the pectin carrier but this was more sustained in the chitosan formulation. Chitosan microspheres loaded with ciprofloxacin hydrochloride were more effective for the treatment of osteomyelitis than equivalent intramuscular antibiotics.en_US
dc.identifier.doi10.1302/0301-620X.88B2.16328
dc.identifier.endpage275en_US
dc.identifier.issn0301-620X
dc.identifier.issn2044-5377
dc.identifier.issue2en_US
dc.identifier.pmid16434537en_US
dc.identifier.scopus2-s2.0-33244494016en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage270en_US
dc.identifier.urihttps://doi.org/10.1302/0301-620X.88B2.16328
dc.identifier.urihttps://hdl.handle.net/20.500.12491/5931
dc.identifier.volume88Ben_US
dc.identifier.wosWOS:000235506600025en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorOrhan, Zafer
dc.institutionauthorAlper, Murat
dc.language.isoenen_US
dc.publisherBritish Editorial Soc Bone Joint Surgeryen_US
dc.relation.ispartofJournal Of Bone And Joint Surgery-British Volumeen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectChitosanen_US
dc.subjectCiprofloxacin
dc.subjectMicrospheres
dc.subjectPectin
dc.subjectAnimals
dc.titleThe preparation of ciprofloxacin hydrochloride-loaded chitosan and pectin microspheres - their evaluation in an animal osteomyelitis modelen_US
dc.typeArticleen_US

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