The effect of the sulfonylurea glyburide on glutathione-S-transferase and glucose-6-phosphate dehydrogenase in streptozotocin-induced diabetic rat liver

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dc.authorid0000-0001-8070-5067en_US
dc.authorid0000-0002-4060-3354en_US
dc.authorid0000-0002-2076-3211
dc.authorid0000-0003-1691-618X
dc.authorid0000-0002-0098-4674
dc.contributor.authorBuğdaycı, Güler
dc.contributor.authorAltan, Nilgün
dc.contributor.authorSancak, Banu
dc.contributor.authorBukan, Neslihan
dc.contributor.authorKosova, Funda
dc.date.accessioned2021-06-23T19:18:44Z
dc.date.available2021-06-23T19:18:44Z
dc.date.issued2006
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractFree radical-induced lipid peroxidation has been associated with numerous disease processes including diabetes mellitus. Glutathione-S-transferase (GST) catalyses the conjugation of glutathione with a variety of organic peroxides to form more water-soluble compounds. Glucose-6-phosphate dehydrogenase (G6PDH) is essential to control intracellular reductive potential by increasing glutathione intracellular levels, which in turn decrease the amount of reactive oxygen species. Glyburide decreases glucose production and enhances insulin action in liver. The aim of this study was to examine the effects of glyburide on the antioxidant enzyme activities in the liver tissue of diabetic rat. We investigated the activities of GST and G6PDH in the liver of both control and streptozotocin-induced diabetic rats. Forty male albino rats were included in this study. Liver GST and G6PDH activities decreased significantly in five-week diabetic rats (p < 0.001 and p < 0.001 respectively) compared to controls and glyburide therapy restored these activities (p < 0.001 for GST and p < 0.001 for G6PDH). Elevations of hepatic antioxidant enzymes with glyburide administration suggest that glyburide may directly alter hepatic enzyme activities.en_US
dc.identifier.doi10.1007/s00592-006-0228-0
dc.identifier.endpage134en_US
dc.identifier.issn0940-5429
dc.identifier.issn1432-5233
dc.identifier.issue4en_US
dc.identifier.pmid17211564en_US
dc.identifier.scopus2-s2.0-33846081029en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage131en_US
dc.identifier.urihttps://doi.org/10.1007/s00592-006-0228-0
dc.identifier.urihttps://hdl.handle.net/20.500.12491/5798
dc.identifier.volume43en_US
dc.identifier.wosWOS:000243353400009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBuğdaycı, Güler
dc.language.isoenen_US
dc.publisherSpringer-Verlag Italia Srlen_US
dc.relation.ispartofActa Diabetologicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntioxidant Enzymesen_US
dc.subjectGlyburideen_US
dc.subjectDiabetesen_US
dc.subjectLiver Tissueen_US
dc.titleThe effect of the sulfonylurea glyburide on glutathione-S-transferase and glucose-6-phosphate dehydrogenase in streptozotocin-induced diabetic rat liveren_US
dc.typeArticleen_US

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