Investigation of in-vitro susceptibility of multidrug-resistant Acinetobacter baumannii strains isolated from clinical specimens to tigecycline

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dc.authorid0000-0002-9026-4485en_US
dc.authorid0000-0003-0727-1797
dc.contributor.authorTaş, Tekin
dc.contributor.authorKocoğlu, Esra
dc.contributor.authorMengeloğlu, Zafer
dc.contributor.authorBucak, Özlem
dc.contributor.authorKarabörk, Şeyda
dc.date.accessioned2021-06-23T19:34:09Z
dc.date.available2021-06-23T19:34:09Z
dc.date.issued2013
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractThe management of infections due to A. baumannii is difficult because of rapidly developing resistance, however, tigecycline, a glycylcyline antimicrobial, is in use for several years. In the present study, it was aimed to determine the susceptibility rates of A. baumannii to tigecycline. A total of 90 A. baumanni isolates were tested using three methods such as disk diffusion, broth microdilution, and E-test. The MIC50 and MIC90 values and the MIC range were found as 2 mu g/ml, 4 mu g/ml, and 0.1-8 mu g/ml by microdilution; and 2 mu g/ml, 6 mu g/ml, and 0.1-12 mu g/ml by E-test, respectively. There were a few major errors as well as the minor rates were all high as between 35.7%-46.7%. The accuracy rates between the methods were low as 53.3% (48/90) between disk diffusion and E-test, 51.1% (46/90) between disk diffusion and microdilution, and 60.0% (54/90) between E-test and microdilution. In the ROC curve analysis, an inhibition zone diameter of susceptibility breakpoint of 21.5 mm had sensitivity between 68.8%-88.9%; specificity between 81.9%-87.9%; and accuracy between 80.0%-83.33%. An analysis based on EUCAST's non-species breakpoints, the MIC tests showed higher accuracy with a rate of 96.7%, however, performance of disk diffusion got worse as lower than 25%. In conclusion, we showed that the reliability of the methods even did not remain as high as the past. Our study presented that none of three methods revealed reliable results in determination of susceptibility of A. baumanni to tigecycline, so the clinical response should be followed up carefully in such cases. (C) 2013 Association of Basic Medical Sciences of FB&H. All rights reserveden_US
dc.identifier.doi10.17305/bjbms.2013.2338
dc.identifier.endpage270en_US
dc.identifier.issn1512-8601
dc.identifier.issn1840-4812
dc.identifier.issue4en_US
dc.identifier.pmid24289764en_US
dc.identifier.scopus2-s2.0-84892511310en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage266en_US
dc.identifier.urihttps://doi.org/10.17305/bjbms.2013.2338
dc.identifier.urihttps://hdl.handle.net/20.500.12491/7401
dc.identifier.volume13en_US
dc.identifier.wosWOS:000330925200011en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorTaş, Tekin
dc.institutionauthorKocoğlu, Esra
dc.institutionauthorMengeloğlu, Zafer
dc.institutionauthorBucak, Özlem
dc.institutionauthorKarabörk, Şeyda
dc.language.isoenen_US
dc.publisherAssoc Basic Medical Sci Federation Bosnia & Herzegovina Sarajevoen_US
dc.relation.ispartofBosnian Journal Of Basic Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTigecyclineen_US
dc.subjectAcinetobacteren_US
dc.subjectMicrodilutionen_US
dc.subjectDisk Diffusionen_US
dc.subjectE-testen_US
dc.titleInvestigation of in-vitro susceptibility of multidrug-resistant Acinetobacter baumannii strains isolated from clinical specimens to tigecyclineen_US
dc.typeArticleen_US

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