Effects of cobalt nitrate on histopathological and morphometric changes in rat femoral artery vasospasm model

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dc.authorid0000-0002-1668-7850
dc.contributor.authorUçar, Saygın
dc.contributor.authorDağıstan, Yaşar
dc.contributor.authorGüler, Ali
dc.date.accessioned2021-06-23T19:43:22Z
dc.date.available2021-06-23T19:43:22Z
dc.date.issued2016
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractObjective: To determine the effects of cobalt nitrate on the arterial wall in a rat femoral artery vasospasm model. Study Design: Experimental study. Place and Duration of Study: Faculty of Medicine, Istanbul University, between November 2009 and September 2010. Methodology: Twenty-four rats were separated into three groups named group 1 (n=8, sham-control); group 2 (n=8, vasospasm), and group 3 (n=8, vasospasm + cobalt nitrate treated). Group 3 rats were subjected to intraperitoneal administration of 0.1 mg/kg/day cobalt nitrate for 7 days, followed by histological and morphometric analyses. ANOVA and post hoc analyses were carried out. Results: The mean vascular wall thickness of the group 1, 2 and 3 rats was found to be 133 13, 210 15 and 160 11 micron, respectively. The mean vascular lumen diameter of the group 1, 2 and 3 rats was 698 20, 240 15 and 540 22 micron, respectively. Arteries in the group 3 had thin smooth endothelium, thin mildly folded internal elastic lamina, and concentric smooth muscle cells. The mean vascular lumen diameter of the group 3 rats showed a significant decrease compared to the group 2 rats. Conclusion: Cobalt nitrate may potentially serve as an agent in preventing cerebral vasospasm after a hemorrhagic episode.en_US
dc.identifier.endpage597en_US
dc.identifier.issn1022-386X
dc.identifier.issn1681-7168
dc.identifier.issue7en_US
dc.identifier.pmid27504552en_US
dc.identifier.scopus2-s2.0-84983628474en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage594en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/8761
dc.identifier.urihttps://www.webofscience.com/wos/woscc/full-record/WOS:000382095900012
dc.identifier.volume26en_US
dc.identifier.wosWOS:000382095900012en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorDağıstan, Yaşar
dc.language.isoenen_US
dc.publisherColl Physicians & Surgeons Pakistanen_US
dc.relation.ispartofJcpsp-Journal Of The College Of Physicians And Surgeons Pakistanen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCobalt Nitrateen_US
dc.subjectSubarachnoid Hemorrhageen_US
dc.subjectFemoral Artery Vasospasmen_US
dc.subjectRaten_US
dc.titleEffects of cobalt nitrate on histopathological and morphometric changes in rat femoral artery vasospasm modelen_US
dc.typeArticleen_US

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