Association of mean platelet volume and red blood cell distribution width with coronary collateral development in stable coronary artery disease

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dc.authorid0000-0002-1495-1697en_US
dc.authorid0000-0003-2399-9585en_US
dc.authorid0000-0001-7306-5233en_US
dc.authoridCoşgun, Mehmet
dc.contributor.authorSincer, İsa
dc.contributor.authorGüneş, Yılmaz
dc.contributor.authorMansıroğlu, Aslı Kurtar
dc.contributor.authorCoşgun, Mehmet
dc.contributor.authorAktaş, Gülali
dc.date.accessioned2021-06-23T19:50:12Z
dc.date.available2021-06-23T19:50:12Z
dc.date.issued2018
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractIntroduction: The prognostic value of hematological indices in cardiovascular diseases and the association between these parameters and cardiovascular conditions have been established in the literature. Aim: In this study, we aimed to investigate the relation of mean platelet volume (MPV), MPV to platelet ratio (MPR) and red cell distribution width (RDW) with degree of coronary collateral development (CCD) in stable coronary artery disease (CAD) subjects with established critical coronary artery stenosis. Material and methods: A total of 306 patients with stable angina pectoris undergoing coronary arteriography were enrolled and divided on the basis of the development of CCD into two groups: a group with adequate CCD (n = 214) and a group with impaired CCD (n = 92). Routine complete blood count and biochemical parameters were measured before coronary arteriography. Results: The MPV and MPR levels were significantly higher in the inadequate CCD group (10.5 +/- 1.8 fl vs. 8.7 +/- 1.9 fl, p < 0.001 and 0.06 +/- 0.08 vs. 0.05 +/- 0.07, p = 0.036). Patients with inadequate CCD had significantly higher RDW levels compared to patients with adequate CCD (15.5 +/- 1.7% vs. 15.0 +/- 1.9%, p = 0.01). MPV and RDW were significantly associated with Rentrop collateral grading (r = -0.523, p < 0.001 and r = -0.239, p < 0.001, respectively), whereas the association with MPR was not significant. An MPV value greater than 9.95 fl, determined with ROC curve analysis, had 71% sensitivity and 70% specificity in predicting inadequate CCD. An RDW greater than 14.3% has 71% sensitivity and 53% specificity in selecting patients with adequate CCD. Conclusions: The present study suggests that MPV and MPR may be associated with the degree of collateral development in chronic stable CAD. However, the negative association of RDW with inadequate CCD, in combination with previous contradictory reports, raises a doubt about the possible value of RDW in stable CAD. Although these parameters may be affected by various conditions, a high MPV may lead clinicians to suspect possible inadequate collateral development in stable CAD patients.en_US
dc.identifier.doi10.5114/aic.2018.78329
dc.identifier.endpage269en_US
dc.identifier.issn1734-9338
dc.identifier.issn1897-4295
dc.identifier.issue3en_US
dc.identifier.pmid30302102en_US
dc.identifier.scopus2-s2.0-85054968760en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage263en_US
dc.identifier.urihttps://doi.org/10.5114/aic.2018.78329
dc.identifier.urihttps://hdl.handle.net/20.500.12491/9725
dc.identifier.volume14en_US
dc.identifier.wosWOS:000445242800008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorSincer, İsa
dc.institutionauthorAktaş, Gülali
dc.language.isoenen_US
dc.publisherTermedia Publishing House Ltden_US
dc.relation.ispartofPostepy W Kardiologii Interwencyjnejen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMean Platelet Volumeen_US
dc.subjectCoronary Collateral Developmenten_US
dc.subjectCoronary Artery Diseaseen_US
dc.subjectRed Cell Distribution Widthen_US
dc.subjectMean Platelet Volume to Platelet Ratioen_US
dc.titleAssociation of mean platelet volume and red blood cell distribution width with coronary collateral development in stable coronary artery diseaseen_US
dc.typeArticleen_US

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