Hashimoto's thyroiditis is associated with elevated serum uric acid to high density lipoprotein-cholesterol ratio

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dc.authorid0000-0002-4162-556en_US
dc.authorid0000-0003-4201-9757en_US
dc.authorid0000-0003-2811-0052en_US
dc.authorid0000-0002-3836-2125en_US
dc.authorid0000-0003-3651-4858en_US
dc.authorid0000-0001-7306-5233en_US
dc.contributor.authorKurtkulağı, Özge
dc.contributor.authorTel, Burçin Meryem Atak
dc.contributor.authorKahveci, Gizem
dc.contributor.authorBilgin, Satılmış
dc.contributor.authorDuman, Tuba Taslamacıoğlu
dc.contributor.authorErtürk, Aslı
dc.contributor.authorBalcı, Buse
dc.contributor.authorAktaş, Gülali
dc.date.accessioned2023-06-08T10:46:48Z
dc.date.available2023-06-08T10:46:48Z
dc.date.issued2021en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground. Hashimoto's thyroiditis (HT) is an auto-immune condition characterized with lymphocytic and fibroblastic infiltration of the thyroid gland. The rate of uric acid and HDL cholesterol - so called as uric acid to HDL ratio (UHR) has been shown to be elevated in inflammatory conditions diseases. We aimed to compare UHR and other laboratory parameters of the patients with HT to those values in healthy controls. Methods. The patients diagnosed with HT by medical history, physical examination, elevated thyroid autoantibodies in serum and characteristic sonographic findings in outpatient internal medicine clinics of our institution were enrolled to the present retrospective study. Age and sex matched healthy volunteers were enrolled as controls. UHR of the HT patients and control subjects were compared. Results. The mean UHR of the HT group was 11% +/- 4 %, while UHR of the control group was 8% +/- 2% (p<0.001). UHR was significantly and positively correlated with thyroid stimulating hormone (TSH) (r=0.26, p=0.01) and negatively correlated with free T4 (FT4) (r=-0.22, p=0.04) levels. The sensitivity and specificity of the UHR level were greater than 8.3%: were 74% and 52%, respectively (AUC: 0.74, p<0.001, 95% CI: 0.64-0.84). Conclusion. We suggest that UHR is a reliable and useful marker for HT. Therefore, it may be helpful in establishing the diagnosis of HT in addition to other diagnostic tools.en_US
dc.identifier.citationKurtkulagi, O., Tel, B. M. A., Kahveci, G., Bilgin, S., Duman, T. T., Ertürk, A., ... & Aktas, G. (2021). Hashimoto’s thyroiditis is associated with elevated serum uric acid to high density lipoprotein-cholesterol ratio. Rom J Intern Med, 59(4), 403-408.en_US
dc.identifier.doi10.2478/rjim-2021-0023
dc.identifier.endpage408en_US
dc.identifier.issn1582-3296
dc.identifier.issn2501-062X
dc.identifier.issue4en_US
dc.identifier.pmid34142519en_US
dc.identifier.scopus2-s2.0-85115157620en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage403en_US
dc.identifier.urihttp://dx.doi.org/10.2478/rjim-2021-0023
dc.identifier.urihttps://hdl.handle.net/20.500.12491/11082
dc.identifier.volume59en_US
dc.identifier.wosWOS:000726787900010en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKurtkulağı, Özge
dc.institutionauthorBilgin, Satılmış
dc.institutionauthorDuman, Tuba Taslamacıoğlu
dc.institutionauthorErtürk, Aslı
dc.institutionauthorBalcı, Buse
dc.language.isoenen_US
dc.publisherSciendoen_US
dc.relation.ispartofRomanian Journal of Internal Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHashimoto's Thyroiditisen_US
dc.subjectUric Acid to HDL Ratioen_US
dc.subjectInflammationen_US
dc.subjectAutoimmuneen_US
dc.subjectDiagnosisen_US
dc.titleHashimoto's thyroiditis is associated with elevated serum uric acid to high density lipoprotein-cholesterol ratioen_US
dc.typeArticleen_US

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