Statins and IL-1 beta, IL-10, and MPO levels in gingival crevicular fluid: preliminary results

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dc.authorid0000-0001-9398-8465en_US
dc.authorid0000-0002-7012-379X
dc.authorid0000-0002-2948-2635
dc.contributor.authorArı, Vuslat Çiçek
dc.contributor.authorİlarslan, Yağmur Deniz
dc.contributor.authorErman, Baran
dc.contributor.authorSarkarati, Bahram
dc.contributor.authorTezcan, İlhan
dc.date.accessioned2021-06-23T19:43:16Z
dc.date.available2021-06-23T19:43:16Z
dc.date.issued2016
dc.departmentBAİBÜ, Rektörlük, Bilimsel Endüstriyel ve Teknolojik Uygulama ve Araştırma Merkezien_US
dc.description.abstractStatins possess a wide variety of pleiotropic properties that are independent of their lipid-lowering abilities such as attenuating inflammation, oxidative stress, coagulation, platelet aggregation and stimulating bone formation. The aim of the study is to evaluate the effect of statins on clinical periodontal parameters and gingival crevicular fluid (GCF) levels of IL-1 beta, IL-10, and myeloperoxidase (MPO) in inflammatory periodontal diseases. Seventy-nine subjects with hyperlipidemia and 48 systemically healthy controls (C) were included. Hyperlipidemic patients were either given a diet (HD) or prescribed statin (HS). Patients were classified into three subgroups as those who were periodontally healthy (h), who had gingivitis (g), or who had chronic periodontitis (p). Blood samples were collected for the measurement of lipid profiles. Plaque index (PI), gingival index (GI), probing pocket depth (PD), clinical attachment level (CAL), and percentage of bleeding on probing (BOP) were recorded. Gingival crevicular fluid levels of IL-1 beta, IL-10, and MPO were measured in order to determine the anti-inflammatory and antioxidant effects of statins. Probing depth values of the HSp group were significantly lower than those of the Cp group. Percentage of BOP of the HSg group was significantly lower than those of the HDg and Cg groups. While the IL-1 beta level of the HSp group was significantly lower than that of the HDp group, IL-10 levels of the HSg group were significantly higher than those of the HDg group. MPO levels were significantly lower in the HSg group when compared to those in the HDg and Cg groups. Statin use decreased the IL-1 beta and MPO levels and enhanced IL-10 in GCF. It can be suggested that statins may attenuate periodontal inflammation and progression of periodontal inflammation.en_US
dc.identifier.doi10.1007/s10753-016-0390-7
dc.identifier.endpage1557en_US
dc.identifier.issn0360-3997
dc.identifier.issn1573-2576
dc.identifier.issue4en_US
dc.identifier.pmid27290718en_US
dc.identifier.scopus2-s2.0-84979031734en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1547en_US
dc.identifier.urihttps://doi.org/10.1007/s10753-016-0390-7
dc.identifier.urihttps://hdl.handle.net/20.500.12491/8736
dc.identifier.volume39en_US
dc.identifier.wosWOS:000380232200030en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorSarkarati, Bahram
dc.language.isoenen_US
dc.publisherSpringer/Plenum Publishersen_US
dc.relation.ispartofInflammationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectStatinsen_US
dc.subjectPeriodontal Diseasesen_US
dc.subjectInflammationen_US
dc.subjectIL-1 Betaen_US
dc.subjectIL-10en_US
dc.titleStatins and IL-1 beta, IL-10, and MPO levels in gingival crevicular fluid: preliminary resultsen_US
dc.typeArticleen_US

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