Is an elevated neutrophil-to-lymphocyte ratio a predictor of metabolic syndrome in patients with chronic obstructive pulmonary disease?

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dc.authorid0000-0002-4641-2866en_US
dc.authorid0000-0002-5078-2958
dc.authorid0000-0003-3746-3095
dc.authorid0000-0003-0700-2546
dc.contributor.authorYaşar, Zehra
dc.contributor.authorBüyükşirin, Melih
dc.contributor.authorÜçsular, Fatma Demirci
dc.contributor.authorKarğı, Aysel
dc.contributor.authorErdem, Fatma
dc.contributor.authorTalay, Fahrettin
dc.contributor.authorKurt, Özlem Kar
dc.date.accessioned2021-06-23T19:42:14Z
dc.date.available2021-06-23T19:42:14Z
dc.date.issued2015
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractOBJECTIVE: This study aimed to evaluate the diagnostic value of the neutrophil-to-lymphocyte ratio (NLR) in early detection of metabolic syndrome (MetS) in patients with chronic obstructive pulmonary disease (COPD). PATIENTS AND METHODS: We retrospectively enrolled hospital records of 140 COPD patients and 50 sex and age-matched healthy controls. The diagnostic values of NLR were estimated using the sensitivity, specificity, and area under the receiver operating characteristic curve (AUC). RESULTS: In total, 140 patients with COPD of which 63 patients had MetS and 50 healthy subjects were included in the study. We found that the NLR values of the stable COPD patients were significantly higher than those of the controls (p < 0.001). Among patients with COPD, the NLR was significantly higher in patients with than without MetS (p < 0.001). The AUC of the NLR was 0.898 in patients with MetS. The optimal NLR cut-off was 2.56 and was validated in the testing set. For evaluation of MetS, the sensitivity and specificity were 84.1% and 84.4% in patients with COPD under the suggested cut-offs. CONCLUSIONS: The NLR is a simple, effective, and practical predictor of MetS in patients with stable COPD. It has potential value in public health practice for management of patients with COPD.en_US
dc.identifier.endpage962en_US
dc.identifier.issn1128-3602
dc.identifier.issue6en_US
dc.identifier.pmid25855919en_US
dc.identifier.scopus2-s2.0-84940727029en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage956en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/8408
dc.identifier.urihttp://www.europeanreview.org/wp/wp-content/uploads/956-962.pdf
dc.identifier.volume19en_US
dc.identifier.wosWOS:000353585700010en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorYaşar, Zehra
dc.institutionauthorTalay, Fahrettin
dc.institutionauthorKurt, Özlem Kar
dc.institutionauthorErdem, Fatma
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical And Pharmacological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectChronic Obstructive Pulmonary Diseaseen_US
dc.subjectMetabolic Syndromeen_US
dc.subjectChronic Systemic Inflammatory Syndromeen_US
dc.subjectNeutrophil-to-lymphocyte Ratioen_US
dc.titleIs an elevated neutrophil-to-lymphocyte ratio a predictor of metabolic syndrome in patients with chronic obstructive pulmonary disease?en_US
dc.typeArticleen_US

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