Relationship between primary nodal generalized osteoarthritis with tissue antigens HLA-A and HLA-B in the Western Black Sea region of Turkey

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dc.authorid0000-0003-0290-9341en_US
dc.authorid0000-0002-2408-5294en_US
dc.authorid0000-0003-3303-9975
dc.contributor.authorTaşlıgil, Cemal
dc.contributor.authorÇoğalgil, Şirzat
dc.contributor.authorTuğ, Esra
dc.contributor.authorTönük, Şükrü Burak
dc.contributor.authorŞahin, Özlem
dc.contributor.authorDoğruer, Dilek
dc.date.accessioned2021-06-23T19:28:38Z
dc.date.available2021-06-23T19:28:38Z
dc.date.issued2011
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractObjective To investigate the relationship between patients diagnosed with nodal generalized osteoarthritis (NGOA) and tissue antigens HLA-A and HLA-B in the Western Black Sea Region of Turkey. Patients and Methods Forty-six patients with NGOA (64.74 +/- 8.46) and 60 controls (62.32 +/- 6.8) were included in the study. Inclusion criteria were: (i) stage 2 and higher OA of the hand and knee based on the Kellgren-Lawrence classification, and (ii) stage 2 and higher lumbar disc degeneration according to Lawrence classification. Family histories were taken from patients. HLA-A and HLA-B were typed by PCR using sequence specific primer. Results The frequencies of HLA-A*02 and HLA-B*38 were 58.7% and 15.2%, respectively, in patients with NGOA, and there was a statistically significant relationship between the disease and HLA-A*02 and HLA-B*38. The relationship between positive family history and HLA-B*44 allele was also statistically significant. In the control group, the frequency of HLA-A*29 was 11.7% and it was statistically significant. Conclusion To our knowledge this is the first study to demonstrate the epidemiologic association between HLA-A*02 and HLA-B*38 with NGOA in our population. We conclude that, HLA-B*44 positivity may be associated with familial NGOA and HLA-A*29 may be a preventive factor against NGOA.en_US
dc.identifier.doi10.2169/internalmedicine.50.4646
dc.identifier.endpage550en_US
dc.identifier.issn0918-2918
dc.identifier.issn1349-7235
dc.identifier.issue6en_US
dc.identifier.pmid21422676en_US
dc.identifier.scopus2-s2.0-84857069272en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage545en_US
dc.identifier.urihttps://doi.org/10.2169/internalmedicine.50.4646
dc.identifier.urihttps://hdl.handle.net/20.500.12491/7038
dc.identifier.volume50en_US
dc.identifier.wosWOS:000289998900003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorTaşlıgil, Cemal
dc.institutionauthorÇoğalgil, Şirzat
dc.institutionauthorTuğ, Esra
dc.institutionauthorTonuk, Burak
dc.institutionauthorŞahin, Özlem
dc.institutionauthorDoğruer, Dilek
dc.language.isoenen_US
dc.publisherJapan Soc Internal Medicineen_US
dc.relation.ispartofInternal Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectprimary nodal generalized osteoarthritisen_US
dc.subjectHLA-A Allellesen_US
dc.subjectHLA-B Allellesen_US
dc.subjectTissue Antigensen_US
dc.titleRelationship between primary nodal generalized osteoarthritis with tissue antigens HLA-A and HLA-B in the Western Black Sea region of Turkeyen_US
dc.typeArticleen_US

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