Diabetes mellitus and female gender are the strongest predictors of poor collateral vessel development in patients with severe coronary artery stenosis

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dc.authorid0000-0001-8862-750X
dc.contributor.authorYetkin, Ertan
dc.contributor.authorTopal, Ergün
dc.contributor.authorErgüzel, Nuri
dc.contributor.authorSenen, Kubilay
dc.contributor.authorHeper, Gülümser
dc.contributor.authorWaltenberger, Johannes
dc.date.accessioned2021-06-23T19:42:10Z
dc.date.available2021-06-23T19:42:10Z
dc.date.issued2015
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground Coronary collateral vessel development (CVD), i.e., arteriogenesis, is regarded as one of the most important mechanisms-along with angiogenesis-to result in protection of the myocardium. Coronary CVD is associated with a reduction in infarct size, future cardiovascular events and improved survival in patients with occlusive coronary artery disease by enhancing regional perfusion in the chronically ischemic myocardium. In the present study, we aimed to investigate the relation of cardiovascular risk factors and hematological parameters with collateral development in patients with severely stenotic (>= 95 %) and totally occluded coronary artery disease including at least one major coronary artery. Materials and methods The study population was selected from the patients who underwent coronary angiography between January 2008 and March 2009. Five hundred and two patients who had at least one coronary artery stenosis >= 95 % (368 men; mean age 59 +/- 10 years) comprised the study population. Of the 502 patients, 228 had total occlusion in at least one major epicardial coronary artery. Collateral artery grading was performed by using Cohen-Rentrop method to the vessel with coronary artery stenosis of >= 95 % and patients with chronic total occlusions (CTO). Patients with grade 0-1 collateral development were regarded as the poor collateral group, and patients with grade 2-3 collateral development were regarded as the good collateral group. Results Two hundred and fifty-eight (51 %) of 502 patients had poor collateral development, and 244 (49 %) had good collateral development. Logistic regression analysis revealed that DM was independently associated with poor CVD in patients with >= 95 % stenosis (p < 0.001). Additionally, female gender and DM were found to be independently associated with poor CVD in patients with CTO (p = 0.005 and p < 0.001, respectively). Monocyte count was found to be independent of CVD neither in patients with >= 95 % stenosis nor in patients with CTO. Conclusion Our data show that DM is an independent factor for poor coronary CVD both in patients with severe coronary artery stenosis and in patients with CTO. Female gender or being in post-menopausal period is another negative risk factor for poor CVD in addition to DM in patients with CTO.en_US
dc.identifier.doi10.1007/s10456-015-9460-y
dc.identifier.endpage207en_US
dc.identifier.issn0969-6970
dc.identifier.issn1573-7209
dc.identifier.issue2en_US
dc.identifier.pmid25680403en_US
dc.identifier.scopus2-s2.0-84925297268en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage201en_US
dc.identifier.urihttps://doi.org/10.1007/s10456-015-9460-y
dc.identifier.urihttps://hdl.handle.net/20.500.12491/8380
dc.identifier.volume18en_US
dc.identifier.wosWOS:000351475400009en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorYetkin, Ertan
dc.institutionauthorErgüzel, Nuri
dc.institutionauthorSenen, Kubilay
dc.institutionauthorHeper, Gülümser
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofAngiogenesisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectArteriogenesisen_US
dc.subjectDiabetes Mellitusen_US
dc.subjectCollateral Vesselen_US
dc.subjectGenderen_US
dc.titleDiabetes mellitus and female gender are the strongest predictors of poor collateral vessel development in patients with severe coronary artery stenosisen_US
dc.typeArticleen_US

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