The evaluation of cognitive functions with P300 test for chronic obstructive pulmonary disease patients in attack and stable period

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dc.authorid0000-0003-2622-5104
dc.authorid0000-0003-4799-5589
dc.authorid0000-0002-7558-9919
dc.authorid0000-0003-1007-7741
dc.authorid0000-0002-7197-2902
dc.contributor.authorKırkıl, Gamze
dc.contributor.authorTuğ, Tuncer
dc.contributor.authorÖzel, Eda
dc.contributor.authorBulut, Serpil
dc.contributor.authorTekataş, Aslan
dc.date.accessioned2021-06-23T19:19:54Z
dc.date.available2021-06-23T19:19:54Z
dc.date.issued2007
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractObjectives: Hypoxia, in chronic obstructive pulmonary disease (COPD), leads to a decrease in cerebral perfusion and an impairment of some cognitive abilities. We aimed to investigate the relation between arterial blood gas analysis (ABA) and pulmonary function test (PFT) parameters with cognitive function of COPD patients during attack and stable period. Patients and methods: ABA, PFT, P300 tests of 30 patients in stabilized period and 30 patients in attack, and 17 healthy controls were evaluated. Results: When both COPD groups and controls were compared, it was seen that latency of P300 was shorter in the control group (p < 0.001), but there was no difference between COPD groups (p > 0.05). P300 amplitude measures were lower in both COPD groups than control group, but it was not statistically significant (p > 0.05). When we compared the measures of attack group, we saw that arterial oxygen tension (PaO2), arterial oxygen saturation (SaO(2)), forced expiratory volume in 1 s (FEV1), FEV1/forced vital capacity (FVC) values increased (p < 0.001), and P300 latency shortened (p < 0.05) in attack group during stable period. P300 latency correlated significantly with PaO2 (r=-0.557, p < 0.001), SaO(2) (r=-0.424, p < 0.001), FEV1 (r=-0.441, p < 0.001), FEV1/FVC (r=-0.477, p < 0.001) values, and age (r=0.329,p < 0.05). P300 amplitude is only correlated with PaO2 (r=0.236,p < 0.05). Conclusion: Longer latency of P300 appears to be an expected sequel of COPD. P300 test can be considered as a potential objective marker of cognitive impairment. (c) 2007 Elsevier B.V. All rights reserved.en_US
dc.identifier.doi10.1016/j.clineuro.2007.03.013
dc.identifier.endpage560en_US
dc.identifier.issn0303-8467
dc.identifier.issn1872-6968
dc.identifier.issue7en_US
dc.identifier.pmid17532116en_US
dc.identifier.scopus2-s2.0-34347331362en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage553en_US
dc.identifier.urihttps://doi.org/10.1016/j.clineuro.2007.03.013
dc.identifier.urihttps://hdl.handle.net/20.500.12491/6023
dc.identifier.volume109en_US
dc.identifier.wosWOS:000248409600002en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorTuğ, Tuncer
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofClinical Neurology And Neurosurgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChronic Obstructive Pulmonary Diseaseen_US
dc.subjectCognitive Functionen_US
dc.subjectP300 Latencyen_US
dc.subjectP300 Amplitudeen_US
dc.subjectPulmonary Function Testen_US
dc.subjectArterial Blood Gas Analysisen_US
dc.titleThe evaluation of cognitive functions with P300 test for chronic obstructive pulmonary disease patients in attack and stable perioden_US
dc.typeArticleen_US

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