The effects of clopidogrel and calcium dobesilate on intimal hyperplasia following vascular injury

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dc.authorid0000-0002-8259-7896
dc.authorid0000-0002-7832-0499
dc.contributor.authorÇörtelekoğlu, Tansel
dc.contributor.authorBozkurt, Ahmet Kürşat
dc.contributor.authorÜstündağ, Nil
dc.contributor.authorKöksal, Cengiz
dc.contributor.authorSayın, Ayla Gürel
dc.date.accessioned2021-06-23T19:19:14Z
dc.date.available2021-06-23T19:19:14Z
dc.date.issued2006
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground : Neo-intimal hyperplasia is one of the most common causes of failure of arterial patency following cardiovascular interventions. It has been proposed that clopidogrel and calcium dobesilate may play an important role in the amelioration of intimal hyperplasia. The aim of this study is to examine the effect of these agents on intimal hyperplasia occurring after experimental balloon catheter injury. Material and Methods : Twenty-four male New Zealand rabbits were divided into three groups. Endothelial injury was caused by introducing a 2.5 x 20 mm balloon angioplasty catheter into the left iliac artery. After the procedure, clopidogrel (25 mg/kg/day/orally) or calcium dobesilate (100 mg/kg/day/orally) were given for 2 weeks. Eight rabbits were given a placebo and served as controls. The contralateral non-injured iliac arteries of the control group were considered as normal iliac artery samples. Iliac artery specimens were examined planimetrically and the intima/media ratio was obtained for each vessel. Results : In the control group, the intima/media ratio was still significantly higher (p < 0.05) than the contralateral normal artery 14 days after the balloon catheter injury. In the clopidogrel and calcium dobesilate groups, this ratio had significantly decreased when compared with the control group (p < 0.05). No significant difference was found when the clopidogrel and calcium dobesilate groups were compared. Conclusion : The anti-agregant agent clopidogrel, and the venous endothelial regulator calcium dobesilate, ameliorate intimal hyperplasia after experimentally induced vascular injury in rabbit iliac arteries.en_US
dc.identifier.endpage210en_US
dc.identifier.issn0001-5458
dc.identifier.issue2en_US
dc.identifier.pmid16761479en_US
dc.identifier.scopus2-s2.0-33646524965en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage206en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/5900
dc.identifier.urihttps://doi.org/10.1080/00015458.2006.11679872
dc.identifier.volume106en_US
dc.identifier.wosWOS:000237514200015en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÜstündağ, Nil
dc.language.isoenen_US
dc.publisherActa Medical Belgicaen_US
dc.relation.ispartofActa Chirurgica Belgicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCalcium Dobesilateen_US
dc.subjectClopidogrelen_US
dc.subjectIntimal Hyperplasiaen_US
dc.subjectPlatelet Inhibitorsen_US
dc.subjectEnddheliumen_US
dc.subjectRestenosisen_US
dc.titleThe effects of clopidogrel and calcium dobesilate on intimal hyperplasia following vascular injuryen_US
dc.typeArticleen_US

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