Could serum uric acid to HDL cholesterol ratio predict sacroiliitis?

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dc.authorid0000-0003-1678-763Xen_US
dc.contributor.authorKalfaoğlu, Melike Elif
dc.date.accessioned2024-06-05T11:58:35Z
dc.date.available2024-06-05T11:58:35Z
dc.date.issued2023en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractRecently, several inflammatory markers, including the uric acid to HDL cholesterol ratio (UHR), triglyceride/HDL cholesterol ratio (THR), systemic inflammatory index (SII), and C-reactive protein to albumin ratio (CAR), have been reported to be associated with inflammatory conditions. However, their collective role in sacroiliitis has not been extensively studied. This study aims to investigate the general characteristics and inflammatory markers in patients with and without sacroiliitis, and to observe any differences in these parameters in subjects with active and chronic sacroiliitis. Patient with sacroiliitis who showed up in the Radiology Department of Abant Izzet Baysal University Hospital were enrolled. Patients diagnosed with sacroiliitis based on clinical symptoms, physical examination, and conventional radiography or MRI findings were included in the sacroiliitis group. Patients without sacroiliitis who present with back pain or hip pain but have normal radiographic findings were included in the control group. General characteristics, including age, sex, body mass index (BMI), medical history, and disease duration, were collected from all participants. Blood samples were collected to measure inflammatory markers, including UHR, THR, SII, and CAR. The collected data were compared between sacroiliitis and control groups. Subgroup analysis was also performed to compare the inflammatory markers between subjects with active and chronic sacroiliitis. The median UHR of the sacroiliitis and control subjects were 11% (3-20%) and 7% (3-13%), respectively (p<0.001). Serum UHR was significantly and positively correlated with CRP (r: 0.4, p = 0.001) and ferritin (r: 0.17, p = 0.045) levels. In ROC analysis, a UHR level higher than 8% has an 81% sensitivity and 64% specificity in detecting sacroiliitis (AUC: 0.8, p<0.001, 95% CI: 0.72-0.84). In conclusion, we suggest that UHR could provide useful data as an additional diagnostic tool in patients with sacroiliitis.en_US
dc.identifier.citationKalfaoglu, M. E. (2023). Could serum uric acid to HDL cholesterol ratio predict sacroiliitis?. Plos one, 18(10), e0289624.en_US
dc.identifier.doi10.1371/journal.pone.0289624
dc.identifier.endpage8en_US
dc.identifier.issn1932-6203
dc.identifier.issue10en_US
dc.identifier.pmid37871023en_US
dc.identifier.scopus2-s2.0-85175165152en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1en_US
dc.identifier.urihttp://dx.doi.org/10.1371/journal.pone.0289624
dc.identifier.urihttps://hdl.handle.net/20.500.12491/12196
dc.identifier.volume18en_US
dc.identifier.wosWOS:001094107000017en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKalfaoğlu, Melike Elif
dc.language.isoenen_US
dc.publisherPublic Library Scienceen_US
dc.relation.ispartofPLOS ONEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectC-Reactive Proteinen_US
dc.subjectAlbumin Ratioen_US
dc.subjectAssociationen_US
dc.titleCould serum uric acid to HDL cholesterol ratio predict sacroiliitis?en_US
dc.typeArticleen_US

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