Healing-promoting effect of bombesin treatment on chronic gastric ulcer in rats

dc.authorid0000-0003-0791-0165en_US
dc.authorid0000-0001-6599-856Xen_US
dc.authorid0000-0001-6990-185X
dc.authorid0000-0002-2186-7258
dc.authorid0000-0001-6279-9602
dc.contributor.authorGünal, Ömer
dc.contributor.authorOktar, Berna K.
dc.contributor.authorÖzçınar, Emine
dc.contributor.authorTansuker, Deniz
dc.contributor.authorArbak, Serap
dc.contributor.authorYeğen, Berrak Ç.
dc.date.accessioned2021-06-23T19:17:26Z
dc.date.available2021-06-23T19:17:26Z
dc.date.issued2002
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractTo evaluate whether bombesin treatment has a facilitatory effect on the healing of chronic gastric ulcer, following the induction of ulcer by serosal application of acetic acid, rats were given bombesin (30 mug/kg/day; subcutaneously) or vehicle three times a day for 7, 14 or 21 days until they were decapitated. Neither food intake nor gastric emptying rate in either vehicle-treated or bombesin-treated groups was not statistically different from control rats. Similarly, ulcer indices and gastric myeloperoxidase (MPO) activities at the first and second weeks of injury were not different among the groups. However, in the 3-week ulcer group, bombesin treatment reduced tissue MPO level significantly back to control levels. Moreover, the analysis of the surface epithelium by scanning electron and light microscopy demonstrated a significant reduction in the severity of ulcers by bombesin treatment. Pretreatment with CCK antagonists (L-364,718 or L365,260; 25 mumol/kg/day) before bombesin treatment showed that neither of the CCK antagonists had a significant effect on the bombes in-mediated healing process, suggesting that CCK receptors are not involved in the action of bombesin. In accordance with the previous studies that show its acute gastroprotective effects, bombesin is also effective in promoting the healing process of chronic gastric ulcer in rats.en_US
dc.identifier.doi10.1016/S0167-0115(02)00055-1
dc.identifier.endpage88en_US
dc.identifier.issn0167-0115
dc.identifier.issue1-3en_US
dc.identifier.pmid12047914en_US
dc.identifier.scopus2-s2.0-0037096142en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage81en_US
dc.identifier.urihttps://doi.org/10.1016/S0167-0115(02)00055-1
dc.identifier.urihttps://hdl.handle.net/20.500.12491/5407
dc.identifier.volume106en_US
dc.identifier.wosWOS:000177027100012en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorGünal, Ömer
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofRegulatory Peptidesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcetic Aciden_US
dc.subjectGastrin-releasing Peptideen_US
dc.subjectUlcer Indexen_US
dc.subjectMyeloperoxidaseen_US
dc.subjectScanning Electron Microscopyen_US
dc.titleHealing-promoting effect of bombesin treatment on chronic gastric ulcer in ratsen_US
dc.typeArticleen_US

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