Preeclampsia: Is it because of the asymptomatic, unrecognized renal scars caused by urinary tract infections in childhood that become symptomatic with pregnancy?

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dc.authorid0000-0002-3156-1076en_US
dc.authorid0000-0003-1719-599
dc.contributor.authorÖzlü, Tülay
dc.contributor.authorAlçelik, Aytekin
dc.contributor.authorÇalışkan, Billur
dc.contributor.authorDönmez, Melahat Emine
dc.date.accessioned2021-06-23T19:28:57Z
dc.date.available2021-06-23T19:28:57Z
dc.date.issued2012
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractPreeclampsia is an important disease of pregnancy whose exact etiology is still unknown despite continuing developments in medicine. Although most commonly it is believed to be caused by a defective placentation, in this paper, we hypothesize that the primary underlying problem in the development of preeclampsia can be in kidneys in a greater proportion of cases than it is believed today. The increased intravascular volume and the increased work load of kidneys together with the resulting glomerular hypertrophy may precipitate nephrotic syndrome, which in this case is called "preeclampsia" in a previously affected kidney. Urinary tract infections in childhood leaving silent, unrecognized small scars in the kidneys may be the underlying renal cause which disrupts its silence with an increased work load of kidneys prominently occurring after the midtrimester. The histopathologic finding in kidneys with renal scars after childhood urinary tract infections and in preeclampsia is focal segmental glomerulosclerosis in the majority of cases and this similarity strengthens our hypothesis. (C) 2012 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.mehy.2012.08.002
dc.identifier.endpage655en_US
dc.identifier.issn0306-9877
dc.identifier.issue5en_US
dc.identifier.pmid22947302en_US
dc.identifier.scopus2-s2.0-84867330184en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage653en_US
dc.identifier.urihttps://doi.org/10.1016/j.mehy.2012.08.002
dc.identifier.urihttps://hdl.handle.net/20.500.12491/7094
dc.identifier.volume79en_US
dc.identifier.wosWOS:000310765300023en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÖzlü, Tülay
dc.institutionauthorAlçelik, Aytekin
dc.institutionauthorÇalışkan, Billur
dc.institutionauthorDönmez, Melahat Emine
dc.language.isoenen_US
dc.publisherChurchill Livingstoneen_US
dc.relation.ispartofMedical Hypothesesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPreeclampsia:en_US
dc.titlePreeclampsia: Is it because of the asymptomatic, unrecognized renal scars caused by urinary tract infections in childhood that become symptomatic with pregnancy?en_US
dc.typeArticleen_US

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