Drug holidays may not affect processing speed while they may reduce beneficial effects on resistance to interference among children with treated with methylphenidate: a single-center, prospective study

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dc.authorid0000-0002-0508-0594en_US
dc.authorid0000-0002-9433-1892en_US
dc.authorid0000-0001-5207-6240en_US
dc.authorid0000-0002-9283-949Xen_US
dc.authorid0000-0002-7925-6783en_US
dc.authorid0000-0002-3412-9879en_US
dc.authorid0000-0001-7535-1735
dc.contributor.authorGöl Özcan, Güler
dc.contributor.authorÖztürk, Yusuf
dc.contributor.authorSarı, Mesut
dc.contributor.authorİmrek, Yasemin
dc.contributor.authorÖzyurt, Gonca
dc.contributor.authorTufan, Ali Evren
dc.contributor.authorAkay, Aynur Pekcanlar
dc.date.accessioned2021-06-23T19:17:08Z
dc.date.available2021-06-23T19:17:08Z
dc.date.issued2020
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractObjective This study aimed to investigate the effects of drug holidays during summer vacations among children with attention deficit/hyperactivity disorder (ADHD) who were treated with methylphenidate in terms of ADHD symptoms and executive functions. Methods The study was a prospective cohort study that includes pre-treatment, post-treatment and post-drug holiday evaluations. ADHD symptom severity was evaluated with the Clinical Global Impression Scale (CGI), the Conners' Parental Rating Scale-Short Form (CPRS) and the Conners' Teacher Rating Scale- Short Form (CTRS). The Stroop Color Word Test- TBAG Form (SCWT) was used to evaluate executive functions. Fifty-one patients participated in the study according to the inclusion and exclusion criteria. Methylphenidate (MPH) was started at 0.5 mg/kg/day and titrated weekly to a maximum of 1.2 mg/kg/day. During the follow-up period, 22 (43.0%) of the patients stopped treatment. Results Completion times for all SCWT subtests were significantly reduced after treatment (p < 0.001, p = 0.002, p < 0.001, p = 0.002, p < 0.001; respectively). Mean number of corrections in SCWT-3 and mean number of errors as well as corrections in SCWT-5 significantly reduced after treatment (p = 0.047, p = 0.005, p = 0.007; respectively). Mean number of corrections in SCWT-3 and mean number of errors in SCWT-5 increased significantly after drug holiday compared to post-treatment (p = 0.032 and p = 0.037; respectively). Conclusion Our results suggest that psychomotor speed and resistance to interference improved in children with ADHD receiving methylphenidate treatment. Drug holidays did not affect psychomotor speed while beneficial effects on resistance to interference were reduced with drug holidays.en_US
dc.identifier.doi10.1080/08039488.2020.1855242
dc.identifier.endpage329
dc.identifier.issn0803-9488
dc.identifier.issue5
dc.identifier.pmid33356759en_US
dc.identifier.scopus2-s2.0-85098595468en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage323
dc.identifier.urihttps://doi.org/10.1080/08039488.2020.1855242
dc.identifier.urihttps://hdl.handle.net/20.500.12491/5239
dc.identifier.volume75
dc.identifier.wosWOS:000603774900001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorGöl Özcan, Güler
dc.institutionauthorTufan, Ali Evren
dc.institutionauthorİmrek, Yasemin
dc.institutionauthorSarı, Mesut
dc.institutionauthorÖztürk, Yusuf
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofNordic Journal Of Psychiatryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectADHD Treatmenten_US
dc.subjectMethylphenidateen_US
dc.subjectExecutive Functionen_US
dc.subjectDrug Holidayen_US
dc.titleDrug holidays may not affect processing speed while they may reduce beneficial effects on resistance to interference among children with treated with methylphenidate: a single-center, prospective studyen_US
dc.typeArticleen_US

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