Dose-related effects of dexamethasone on liver damage due to bile duct ligation in rats

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dc.authorid0000-0001-5608-5742
dc.authorid0000-0003-1719-4924
dc.authorid0000-0002-7168-1507
dc.contributor.authorEken, Halil
dc.contributor.authorÖztürk, Hayrettin
dc.contributor.authorÖztürk, Hülya
dc.contributor.authorBüyükbayram, Hüseyin
dc.date.accessioned2021-06-23T19:18:53Z
dc.date.available2021-06-23T19:18:53Z
dc.date.issued2006
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractAIM: To evaluate the effects of dexamethasone on liver damage in rats with bile duct ligation. METHODS: A total of 40 male Sprague-Dawley rats, weighing 165-205 g, were used in this study. Group 1 (sham-control, n = 10) rats underwent laparotomy alone and the bile duct,was just dissected from the surrounding tissue. Group 2 rats (untreated, n = 10) were subjected to bile duct ligation (BDL) and no drug was applied. Group 3 rats (low-dose dexa, n = 10) received a daily dose of dexamethasone by orogastric tube for 14 d after BDL. Group 4 rats (high-dose dexa, n = 10) received a daily dose of dexamethasone by orogastric tube for 14 d after BDL. At the end of the two-week period, biochemical and histological evaluations were processed. RESULTS: The mean serum bilirubin and liver enzyme levels significantly decreased, and superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) values were significantly increased in low-dose dexa and high-dose dexa groups when compared to the untreated group. The histopathological score was significantly less in the low-close and high-dose dexa groups compared to the untreated rats. In the low-dose dexa group, moderate liver damage was seen, while mild liver damage was observed in the high-dose dexa group. CONCLUSION: Corticosteroids reduced liver damage produced by bile duct obstruction. However, the histopathological score was not significantly lower in the high-dose corticosteroid group as compared to the low-dose group. Thus, low-dose corticosteroid provides a significant reduction of liver damage without increased side effects, while high dose is associated not with lower fibrosis but with increased side effects.en_US
dc.identifier.doi10.3748/wjg.v12.i33.5379
dc.identifier.endpage5383en_US
dc.identifier.issn1007-9327
dc.identifier.issn2219-2840
dc.identifier.issue33en_US
dc.identifier.pmid16981272en_US
dc.identifier.scopus2-s2.0-33749389903en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage5379en_US
dc.identifier.urihttps://doi.org/10.3748/wjg.v12.i33.5379
dc.identifier.urihttps://hdl.handle.net/20.500.12491/5831
dc.identifier.volume12en_US
dc.identifier.wosWOS:000240646900020en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÖztürk, Hayrettin
dc.language.isoenen_US
dc.publisherBaishideng Publishing Group Incen_US
dc.relation.ispartofWorld Journal Of Gastroenterologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBile Duct Ligationen_US
dc.subjectHepatic Fibrosisen_US
dc.subjectDexamethasoneen_US
dc.titleDose-related effects of dexamethasone on liver damage due to bile duct ligation in ratsen_US
dc.typeArticleen_US

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