Two different doses of caudal neostigmine co-administered with levobupivacaine produces analgesia in children

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dc.authorid0000-0001-5406-098Xen_US
dc.authorid0000-0003-0582-8723
dc.authorid0000-0001-5608-5742
dc.authorid0000-0001-5406-098X
dc.authorid0000-0002-0363-9307
dc.contributor.authorKaraaslan, Kazım
dc.contributor.authorGülcü, Nebahat
dc.contributor.authorÖztürk, Hayrettin
dc.contributor.authorSarpkaya, Ali
dc.contributor.authorÇolak, Cemil
dc.contributor.authorKoçoğlu, Hasan
dc.date.accessioned2021-06-23T19:26:17Z
dc.date.available2021-06-23T19:26:17Z
dc.date.issued2009
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractThis study was aimed to evaluate the analgesic efficacy, duration of analgesia, and side effects of two different doses of caudal neostigmine used with levobupivacaine in children. Sixty boys, between 5 months and 5 years, undergoing genito-urinary surgery were allocated randomly to one of three groups (n = 20 each). Group I patients received caudal 0.25% levobupivacaine (1 ml.kg(-1)) alone. Groups II and III patients received neostigmine (2 and 4 mu g.kg(-1) respectively) together with levobupivacaine used in the same dose as Group I. Pain scores were assessed using Children's and Infant's Postoperative Pain Scale (CHIPPS) at 15th (t(1)) min after arrival to postanesthetic care unit, and 1st (t(2)), 2nd (t(3)), 3rd (t(4)), 4th (t(5)), 8th (t(6)), 16th (t(7)), and 24th (t(8)) hour postoperatively. Duration of analgesia, amount of additional analgesic (paracetamol), score of motor blockade and complications were recorded for 24 h postoperatively, and compared between groups. CHIPPS scores were higher during t(2), t(3), t(6), t(7) and t(8) periods, duration of analgesia was shorter, and total analgesic consumption was higher in Group I compare to neostigmine groups (P < 0.05). Duration of postoperative analgesia and total analgesic consumption were similar in Groups II and III (P > 0.05). Adverse effects were not different between three groups. Caudal neostigmine in doses of 2 and 4 mu g.kg(-1) with levobupivacaine extends the duration of analgesia without increasing the incidence of adverse effects, and 2 mu g.kg(-1) seems to be the optimal dose, as higher dose has no further advantages.en_US
dc.identifier.doi10.1111/j.1460-9592.2009.02969.x
dc.identifier.endpage493en_US
dc.identifier.issn1155-5645
dc.identifier.issn1460-9592
dc.identifier.issue5en_US
dc.identifier.pmid19565667en_US
dc.identifier.scopus2-s2.0-65349113052en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage487en_US
dc.identifier.urihttps://doi.org/10.1111/j.1460-9592.2009.02969.x
dc.identifier.urihttps://hdl.handle.net/20.500.12491/6488
dc.identifier.volume19en_US
dc.identifier.wosWOS:000265511700011en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKaraaslan, Kazım
dc.institutionauthorGülcü, Nebahat
dc.institutionauthorSarpkaya, Ali
dc.institutionauthorKoçoğlu, Hasan
dc.language.isoenen_US
dc.publisherWiley-Blackwellen_US
dc.relation.ispartofPediatric Anesthesiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectLevobupivacaineen_US
dc.subjectNeostigmineen_US
dc.subjectCaudal Blocken_US
dc.subjectPostoperative Analgesiaen_US
dc.titleTwo different doses of caudal neostigmine co-administered with levobupivacaine produces analgesia in childrenen_US
dc.typeArticleen_US

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