The Effects of Splenectomy and Splenic Autotransplantation on Plasma Lipid Levels

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dc.authorid0000-0002-3487-1264
dc.contributor.authorAkan, Arzu Atalay
dc.contributor.authorŞengül, Neriman
dc.contributor.authorŞimşek, Şerife
dc.contributor.authorDemirer, Seher
dc.date.accessioned2021-06-23T19:21:01Z
dc.date.available2021-06-23T19:21:01Z
dc.date.issued2008
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractPurpose: Atherosclerosis observations after splenectomy for trauma and hypersplenism suggests a possible role for the spleen in lipid metabolism. The authors examined the effects of splenectomy on serum lipids in rats and also cholesterol-fed rats with experimental atherosclerosis. Methods: This study was designed on rats. The rats were divided into five groups: splenectomy, normal diet (SP-N, n: 8), splenectomy, cholesterol-fed groups (SP-C, n: 8), splenic autotransplantation after splenectomy, normal diet (SA-N, n: 8), splenic autotransplantation after splenectomy, cholesterol-fed groups (SA-C, n: 8) and sham groups (n: 8). Total triglyceride, total cholesterol, HDL (high-density lipoprotein), LDL (low-density lipoprotein), and VLDL (very low-density lipoprotein) levels were determined in 40 rats. The rats were classified into five groups based on the surgical procedures. The spleens were removed and then the rats were fed a normal diet in Group SP-N (n = 8). The spleens were removed and then the rats were fed a diet containing 1% cholesterol in Group SP-C (n = 8). Splenectomy and splenic autotransplantations were performed and then the rats were fed a normal diet in Group SA-N (n = 8). Splenectomy and splenic autotransplantations were performed and then the rats were fed a diet containing 1% cholesterol in Group SA-C (n = 8). The rats were sham-operated in the control group (Group S, n = 8). An active splenic function was shown in rats that underwent splenic autotransplantation in both groups by using Technicium 99 in sulphurcolloide sintiscan on day 30. Blood lipid levels were repeated 6 months later. Results: There was no difference between pre- and postoperative lipid levels in the sham group and SA-N group (P > .05). All lipid levels including HDL were increased significantly in SP-C group (P < .05). Also VLDL and total tryglyceride levels were increased significantly in SP-N and SAC groups (p < .05). Conclusions: This study showed that the spleen might have an important effect on lipid metabolism and splenic autotransplantation may be protective in conditions with increased lipid levels.en_US
dc.identifier.doi10.1080/08941930802438898
dc.identifier.endpage372en_US
dc.identifier.issn0894-1939
dc.identifier.issn1521-0553
dc.identifier.issue6en_US
dc.identifier.pmid19160147en_US
dc.identifier.scopus2-s2.0-61749099276en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage369en_US
dc.identifier.urihttps://doi.org/10.1080/08941930802438898
dc.identifier.urihttps://hdl.handle.net/20.500.12491/6203
dc.identifier.volume21en_US
dc.identifier.wosWOS:000262848100010en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorŞengül, Neriman
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofJournal Of Investigative Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSpleenen_US
dc.subjectLipid Metabolismen_US
dc.subjectSplenectomyen_US
dc.subjectSplenic Autotransplantationen_US
dc.titleThe Effects of Splenectomy and Splenic Autotransplantation on Plasma Lipid Levelsen_US
dc.typeArticleen_US

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