Investigation of virulence factors and determination of antifungal susceptibilities of candida strains isolated at Suleyman Demirel University Hospital

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dc.authorid0000-0002-5643-3038
dc.authorid0000-0002-9502-4018
dc.authorid0000-0003-0980-2205
dc.authorid0000-0001-5231-3824
dc.contributor.authorAynalı, Ayşe
dc.contributor.authorKaya, Selçuk
dc.contributor.authorArıdoğan, Buket Cicioğlu
dc.contributor.authorÇetin, Emel Sesli
dc.contributor.authorTaş, Tekin
dc.date.accessioned2021-06-23T19:36:49Z
dc.date.available2021-06-23T19:36:49Z
dc.date.issued2014
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractObjective: The aim of this study was to evaluate the virulence factors and antifungal susceptibilities of Candida strains, which were isolated from various clinical specimens. Methods: One-hundred Candida strains were identified. Bovine serum albumin agar was used to investigate proteinase production and egg yolk agar was used to test phospholipase production. Modified tube adherence method was used for investigation of slime activity. The antifungal susceptibilities of the strains for amphotericin B, fluconazole, voriconazole and caspofungin were evaluated by using reference broth microdilution method. Results: Forty-eight percent (n=48) of the Candida strains were identified as C. albicans which represented the most common species. Both proteinase and phospholipase production rates were significantly higher among C. albicans isolates (79%; 66%) than non albicans Candida strains (11.5%; 0%) (r=33.22, p<0.001 and r=206.8, p<0.001 repectively). On the other hand, slime activity was significantly higher among non-albicans strains (30%) when compered with C. albicans (0%) (r=0.228, p<0.001). MIC ranges were found as 0.03-1 mu g/mL, 0.125 - >= 64 mu g/L, 0.03-2,mu g/mL and 0.015-2 mu g/mL for amphotericin B, fluconazole, voriconazole and caspofungin respectively. Conclusion: Proteinase and phospholipase activities can be suggested as important virulence factors in C. albicans infections, while the slime factor production seems to be more important in non-albicans Candida infections. In addition, amphotericin-B, voriconazole and caspofungin can be suggested to be effective on Candida strains and may be used as alternative drugs for treatment of infections caused by fluconazole-resistant strains.en_US
dc.identifier.endpage395en_US
dc.identifier.issn0393-6384
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-84898477426en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage391en_US
dc.identifier.urihttps://www.actamedicamediterranea.com/archive/2014/medica-2/investigation-of-virulence-factors-and-determination-of-antifungal-susceptibilities-of-candida-strainsisolated-at-suleyman-demirel-university-hospital/document
dc.identifier.urihttps://hdl.handle.net/20.500.12491/8059
dc.identifier.volume30en_US
dc.identifier.wosWOS:000335937900016en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorTaş, Tekin
dc.language.isoenen_US
dc.publisherCarbone Editoreen_US
dc.relation.ispartofActa Medica Mediterraneaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCandidaen_US
dc.subjectC. Albicansen_US
dc.subjectVirulence Factorsen_US
dc.subjectAntifungal Susceptibilityen_US
dc.titleInvestigation of virulence factors and determination of antifungal susceptibilities of candida strains isolated at Suleyman Demirel University Hospitalen_US
dc.typeArticleen_US

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