The effects of the time of the day and the pinealectomy on anxiety-like behaviour in male Wistar rats

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dc.contributor.authorKaya, Aliye
dc.contributor.authorKarakaş, Alper
dc.contributor.authorCoşkun, Hamit
dc.date.accessioned2021-06-23T19:28:29Z
dc.date.available2021-06-23T19:28:29Z
dc.date.issued2011
dc.departmentBAİBÜ, Fen Edebiyat Fakültesi, Biyoloji Bölümüen_US
dc.description.abstractThe previous studies on the anxiety-like behaviour in rats by using elevated plus maze and open field have provided rather unequivocal results because they obtained data at different times of the day. These studies have never investigated the effects of the different times of day in a single research paradigm even though the results of such studies are generally attributed to the different measurement times. Thus, we aimed to examine the effects of the time of the day and the pinealectomy on anxiety-like behaviour in male Wistar albino rats by using elevated plus maze and open field in this study. Experiments were performed with control and pinealectomy groups at the four different time points (6:00, 12:00, 18:00 and 24:00 hr; LD 12:12, lights on at 6:00 h and off at 18:00 h). In open field, the main effect of the measurement time was significant on the total distance travelled, the mobility and the velocity. In elevated plus maze, the main effect of the measurement time was significant on the total distance travelled, the total entry to closed arms and mobility. The main effect of the pinealectomy was insignificant on all of the measured parameters in both open field and elevated plus maze except for the total entry to closed arms in elevated plus maze. The results of the present study showed for the first time that the time of the day when the measurements are performed is important on the anxiety-like behaviour of the Wistar albino rats.en_US
dc.identifier.doi10.1080/09291016.2010.525380
dc.identifier.endpage383en_US
dc.identifier.issn0929-1016
dc.identifier.issn1744-4179
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-80052990788en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage367en_US
dc.identifier.urihttps://doi.org/10.1080/09291016.2010.525380
dc.identifier.urihttps://hdl.handle.net/20.500.12491/7026
dc.identifier.volume42en_US
dc.identifier.wosWOS:000299786700002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorKaya, Aliye
dc.institutionauthorKarakaş, Alper
dc.institutionauthorCoşkun, Hamit
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiological Rhythm Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTime of The Dayen_US
dc.subjectPineal Glanden_US
dc.subjectMelatoninen_US
dc.subjectAnxietyen_US
dc.subjectElevated Plus Mazeen_US
dc.subjectOpen Fielden_US
dc.titleThe effects of the time of the day and the pinealectomy on anxiety-like behaviour in male Wistar ratsen_US
dc.typeArticleen_US

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