Maternal serum soluble HLA-G levels in missed abortions

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dc.contributor.authorKeskin, Fatih
dc.contributor.authorKarataş, Ahmet
dc.contributor.authorAlbayrak, Mustafa
dc.contributor.authorBıyık, İsmail
dc.contributor.authorErkan, Müşerref
dc.date.accessioned2021-06-23T19:34:54Z
dc.date.available2021-06-23T19:34:54Z
dc.date.issued2013
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground and Objective. It is unclear how immune tolerance develops to a semiallograft fetus in pregnancy. Human leukocyte antigen G (HLA-G) expressed by extravascular trophoblasts plays an important role in the recognition of the gestational tissues as self and the development of immune tolerance against the gestational tissues by the maternal immune system. The soluble form of the HLA-G (sHLA-G) molecule in the maternal serum is also reported to contribute to the prevention of rejection during pregnancy. The aim of the study was to compare the maternal serum sHLA-G levels of the women with missed abortions and control subjects with uncomplicated pregnancies. Material and Methods. The prospective cross-sectional study involving 40 with missed abortions and 40 control women, matched by age, gestational age, and body mass index, was carried out. The study group consisted of the women with singleton pregnancies, who were diagnosed with a missed abortion. Only the patients who were confirmed to have an uncomplicated term delivery during follow-up were included in the control group. The serum sHLA-G level was compared between the groups. Results. There was no significant difference in the mean serum sHLA-G levels in terms of gravidity (P=0.761) and a history of abortion (P=0.379) in the control group. The median serum sHLA-G level in the missed abortion group was significantly lower compared with the control group (16.8 [8.5-35.8] vs. 26 [11-135] U/mL, P<0.001). All the women in the control group had uncomplicated term deliveries. Conclusion. Our results showed that the women with missed abortions had significantly lower serum sHLA-G levels compared with the healthy pregnant controls, which may have potentially played a role in the impairment of physiological immunological tolerance during pregnancy. However, the determination of the exact role and the potential clinical utility of maternal serum sHLA-G for the detection/ prediction of a missed abortion risk requires further detailed studies.en_US
dc.identifier.endpage438en_US
dc.identifier.issn1648-9144
dc.identifier.issue10en_US
dc.identifier.pmid24709785en_US
dc.identifier.scopus2-s2.0-84898766283en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage435en_US
dc.identifier.urihttps://doi.org/10.3390/medicina49100068
dc.identifier.urihttps://hdl.handle.net/20.500.12491/7656
dc.identifier.volume49en_US
dc.identifier.wosWOS:000333793200002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKarataş, Ahmet
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofMedicina-Lithuaniaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPregnancy Lossen_US
dc.subjectsHLA-Gen_US
dc.subjectEarly Pregnancyen_US
dc.subjectMissed Abortionen_US
dc.titleMaternal serum soluble HLA-G levels in missed abortionsen_US
dc.typeArticleen_US

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