Oxygen-dependent bactericidal activity of leukocytes in patients with type 2 diabetes mellitus

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dc.authorid0000-0002-7361-8181
dc.authorid0000-0001-7432-9915
dc.contributor.authorKanat, Mustafa
dc.contributor.authorDonma, Orkide
dc.contributor.authorAygün, Cem
dc.contributor.authorSardoğan, Emine
dc.contributor.authorEkmekçi, Özlem Balcı
dc.date.accessioned2021-06-23T18:52:13Z
dc.date.available2021-06-23T18:52:13Z
dc.date.issued2009
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractObjective: In this study it is aimed to investigate the oxygen-dependent bactericidal activity of leukocytes in patients with diabetes mellitus type 2. Materials and Methods: All the data obtained from 28 patients with diabetes mellitus were compared with 31 demographically matched control individuals. Leukocytes of patients with diabetes mellitus and healthy control group were separated from blood samples for determination of oxygen-dependent antimicrobial activity enzymes including superoxide dismutase (SOD), glutathione reductase (GSH-R), gluthatione peroxidase (GSH-Px) and catalase. As lipid peroxidation products, thiobarbituric acid reactive substances (TBARS) were measured. Results: SOD, GSH-R, and catalase activities of patients with type 2 diabetes were not significantly different from control group (p>0.05). GSH-Px levels of patients with diabetes mellitus were significantly lower than control group (0.012±0.08 U/mg.pr versus 0.057±0.046 U/mg.pr, p<0.05). Measurements of TBARS were not different between patients with diabetes mellitus and control group (5.49±1.31 ?mol/l versus 5.53±1.45 ?mol/l, p=0.905). Conclusions: It is difficult to suggest that in patients with diabetes mellitus the tendency to some known infections is due to alteration in oxygen-dependent bactericidal activity of leukocytes.en_US
dc.identifier.endpage24en_US
dc.identifier.issn1301-2193
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-73449123748en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage20en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/4169
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-73449123748&partnerID=40&md5=70df4650bff620c8ff040d738f3a160d
dc.identifier.volume13en_US
dc.identifier.wosWOS:000217297100002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorKanat, Mustafa
dc.language.isoenen_US
dc.publisherTurkiye Kliniklerien_US
dc.relation.ispartofTurkish Journal of Endocrinology and Metabolismen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOxygen Dependent Bactericidal Activityen_US
dc.subjectTip 2 Diabetes Mellitusen_US
dc.titleOxygen-dependent bactericidal activity of leukocytes in patients with type 2 diabetes mellitusen_US
dc.typeArticleen_US

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