Oxygen-dependent bactericidal activity of leukocytes in patients with type 2 diabetes mellitus
Küçük Resim Yok
Tarih
2009
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Turkiye Klinikleri
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: In this study it is aimed to investigate the oxygen-dependent bactericidal activity of leukocytes in patients with diabetes mellitus type 2. Materials and Methods: All the data obtained from 28 patients with diabetes mellitus were compared with 31 demographically matched control individuals. Leukocytes of patients with diabetes mellitus and healthy control group were separated from blood samples for determination of oxygen-dependent antimicrobial activity enzymes including superoxide dismutase (SOD), glutathione reductase (GSH-R), gluthatione peroxidase (GSH-Px) and catalase. As lipid peroxidation products, thiobarbituric acid reactive substances (TBARS) were measured. Results: SOD, GSH-R, and catalase activities of patients with type 2 diabetes were not significantly different from control group (p>0.05). GSH-Px levels of patients with diabetes mellitus were significantly lower than control group (0.012±0.08 U/mg.pr versus 0.057±0.046 U/mg.pr, p<0.05). Measurements of TBARS were not different between patients with diabetes mellitus and control group (5.49±1.31 ?mol/l versus 5.53±1.45 ?mol/l, p=0.905). Conclusions: It is difficult to suggest that in patients with diabetes mellitus the tendency to some known infections is due to alteration in oxygen-dependent bactericidal activity of leukocytes.
Açıklama
Anahtar Kelimeler
Oxygen Dependent Bactericidal Activity, Tip 2 Diabetes Mellitus
Kaynak
Turkish Journal of Endocrinology and Metabolism
WoS Q Değeri
N/A
Scopus Q Değeri
Q4
Cilt
13
Sayı
2
