The effect of resveratrol and glibenclamide on ischemia/reperfusion induced arrhythmias in STZ-induced diabetic rats
Yükleniyor...
Tarih
2016
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley-Blackwell
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Context: Cardiovascular dysfunctions such as life-threatening arrhythmias are one of the main reasons
of mortality and morbidity in diabetic patients
Objective: We aimed to investigate the long-term effects of resveratrol, berberine and glibenclamide
combinations on the ischemia/reperfusion (I/R) induced arrhythmias in streptozotocin (STZ)-induced
diabetic rats and to investigate the role of myocardial KATP channel in the possible anti-arrhythmic actions of the treatments.
Methods: Two days after induction of diabetes, diabetic rats were treated with resveratrol [5 mg/kg,
intraperitoneally (i.p.)], berberine (10 mg/kg, i.p) and glibenclamide (5 mg/kg, i.p) for 6 weeks. On the
43th day, experimental animals were subjected to 6-min ischemia and 6-min reperfusion in vivo.
Results: The protein expression of Kir6.2 subunits was downregulated in the diabetic hearts. However,
all drug treatments restored the protein expression of Kir6.2 subunits. Resveratrol alone and its combination with glibenclamide decreased the arrhythmia score, the arrhythmic period and the incidence of other types of arrhythmias during the reperfusion period.
Conclusions: The combination of resveratrol with glibenclamide may alleviate reperfusion-induced
arrhythmias via an underlying mechanism not be only associated with the restoration of the protein expression of Kir6.2 subunits but also associated with the other subunits or ion channels underlying cardiac action potential.
Açıklama
Anahtar Kelimeler
Resveratrol, Glibenclamide, Diabetic Rat, Arrhythmia
Kaynak
Acta Physiologica
WoS Q Değeri
Q1
Scopus Q Değeri
Cilt
218
