The effect of resveratrol and glibenclamide on ischemia/reperfusion induced arrhythmias in STZ-induced diabetic rats

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dc.authorid0000-0002-4133-407X
dc.authorid0000-0001-5073-0691
dc.authorid0000-0002-2635-7011
dc.authorid0000-0002-8317-7092
dc.authorid0000-0002-9677-8823
dc.contributor.authorKaya, Salih Tunç
dc.contributor.authorÖzaslan, Oğulcan Talat
dc.contributor.authorEkşioglu, Didem
dc.contributor.authorErim, Firdevs
dc.contributor.authorYaşar, Selçuk
dc.contributor.authorBozdoğan, Ömer
dc.contributor.authorFırat, Tülin
dc.date.accessioned2021-06-23T19:43:04Z
dc.date.available2021-06-23T19:43:04Z
dc.date.issued2016
dc.departmentBAİBÜ, Fen Edebiyat Fakültesi, Biyoloji Bölümüen_US
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
dc.description.abstractContext: Cardiovascular dysfunctions such as life-threatening arrhythmias are one of the main reasons of mortality and morbidity in diabetic patients Objective: We aimed to investigate the long-term effects of resveratrol, berberine and glibenclamide combinations on the ischemia/reperfusion (I/R) induced arrhythmias in streptozotocin (STZ)-induced diabetic rats and to investigate the role of myocardial KATP channel in the possible anti-arrhythmic actions of the treatments. Methods: Two days after induction of diabetes, diabetic rats were treated with resveratrol [5 mg/kg, intraperitoneally (i.p.)], berberine (10 mg/kg, i.p) and glibenclamide (5 mg/kg, i.p) for 6 weeks. On the 43th day, experimental animals were subjected to 6-min ischemia and 6-min reperfusion in vivo. Results: The protein expression of Kir6.2 subunits was downregulated in the diabetic hearts. However, all drug treatments restored the protein expression of Kir6.2 subunits. Resveratrol alone and its combination with glibenclamide decreased the arrhythmia score, the arrhythmic period and the incidence of other types of arrhythmias during the reperfusion period. Conclusions: The combination of resveratrol with glibenclamide may alleviate reperfusion-induced arrhythmias via an underlying mechanism not be only associated with the restoration of the protein expression of Kir6.2 subunits but also associated with the other subunits or ion channels underlying cardiac action potential.en_US
dc.identifier.endpage14en_US
dc.identifier.issn1748-1708
dc.identifier.issn1748-1716
dc.identifier.startpage14en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/8681
dc.identifier.urihttps://www.webofscience.com/wos/woscc/full-record/WOS:000383578300037
dc.identifier.volume218en_US
dc.identifier.wosWOS:000383578300037en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.institutionauthorBozdoğan, Ömer
dc.institutionauthorÖzaslan, Oğulcan Talat
dc.institutionauthorEkşioglu, Didem
dc.institutionauthorErim, Firdevs
dc.institutionauthorYaşar, Selçuk
dc.institutionauthorFırat, Tülin
dc.language.isoenen_US
dc.publisherWiley-Blackwellen_US
dc.relation.ispartofActa Physiologicaen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectResveratrolen_US
dc.subjectGlibenclamide
dc.subjectDiabetic Rat
dc.subjectArrhythmia
dc.titleThe effect of resveratrol and glibenclamide on ischemia/reperfusion induced arrhythmias in STZ-induced diabetic ratsen_US
dc.typeConference Objecten_US

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