The effect of surgical menopause on the intima-media thickness of the carotid and coronary arteries

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dc.authorid0000-0001-7573-0719
dc.authorid0000-0001-5502-7751
dc.authorid0000-0002-6326-7234
dc.contributor.authorÖzdemirci, Şafak
dc.contributor.authorKasapoğlu, Taner
dc.contributor.authorDilbaz, Berna
dc.contributor.authorSalgür, Funda
dc.contributor.authorDuran, Bülent
dc.contributor.authorKoç, Önder
dc.date.accessioned2021-06-23T19:43:00Z
dc.date.available2021-06-23T19:43:00Z
dc.date.issued2016
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractObjective: To evaluate the effect of prior bilateral oophorectomy on the intima-media thickness (IMT) of coronary and carotid arteries. Methods: A total of 25 Wistar albino rats, aged 8-10 weeks, were assigned to three groups: ovariectomized (n=10), control (n=10) and sham (n = 5). The rats in the sham group only underwent mid line laparotomy, while the other rats' ovaries were removed by the same type of laparotomy. All rats were sacrificed to evaluate microscopically the impact of a prolonged 26-week surgical menopause (menopausal period) on the IMT of the carotid and coronary arterial structure. Results: The mean IMTs of both the carotid and coronary arteries in the ovariectomized group were significantly thicker than those of the control and sham groups (carotid arteries: 268.69 +/- 53.67, 195.61 +/- 47.60 and 193.86 +/- 75.01 mu m, p = 0.014; coronary arteries: 182.40 +/- 30.22, 136.00 +/- 35.82 and 165.24 +/- 40.68 m, p = 0.022, respectively). Conclusion: According to the results of this study, surgical menopause results in a noteworthy increase in the IMT of the carotid and coronary arteries when compared with the controls. This interventional effect may have a significant role in accelerating the process of atherosclerosis.en_US
dc.identifier.doi10.1080/13697137.2016.1212007
dc.identifier.endpage457en_US
dc.identifier.issn1369-7137
dc.identifier.issn1473-0804
dc.identifier.issue5en_US
dc.identifier.pmid27538242en_US
dc.identifier.scopus2-s2.0-84982245107en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage452en_US
dc.identifier.urihttps://doi.org/10.1080/13697137.2016.1212007
dc.identifier.urihttps://hdl.handle.net/20.500.12491/8665
dc.identifier.volume19en_US
dc.identifier.wosWOS:000383943300011en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorDuran, Bülent
dc.institutionauthorKoç, Önder
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofClimactericen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCarotid Arteryen_US
dc.subjectCoronary Arteryen_US
dc.subjectIntima-Media Thicknessen_US
dc.subjectMenopauseen_US
dc.subjectOvariectomyen_US
dc.subjectRatsen_US
dc.titleThe effect of surgical menopause on the intima-media thickness of the carotid and coronary arteriesen_US
dc.typeArticleen_US

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