Topical cyclosporine-A combined with mitomycin C for conjunctival and corneal squamous cell carcinoma

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dc.contributor.authorTunç, Murat
dc.contributor.authorErbilen, Esin
dc.date.accessioned2021-06-23T19:18:50Z
dc.date.available2021-06-23T19:18:50Z
dc.date.issued2006
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractPURPOSE: To determine the efficiency of topical cyclosporine,A (CSA) combined with mitomycin C (MMC) as an adjunctive treatment in diffuse conjunctival and corneal squamous cell carcinoma (CCSC). DESIGN: Interventional case reports. METHODS: Two patients who had positive margins following surgical excision of CCSC were treated by topical CSA (0.05%) four times a day for 12 weeks, and topical MMC (0.01%) four times a day was combined with CSA at the second, fourth, and sixth weeks of the treatment. We controlled the tumor recurrence, vision, and ocular surface healing during the follow-up. RESULTS: There was no tumor recurrence during the follow up of 18 months. Limbal vascularization regressed considerably and the vision improved without any ocular surface problems in both patients. CONCLUSIONS: As an adjunctive treatment, topical CSA (0.05%) combined with MMC (0.01%), may prevent tumor recurrence and provide excellent ocular surface healing in diffuse CCSC.en_US
dc.identifier.doi10.1016/j.ajo.2006.05.003
dc.identifier.endpage675en_US
dc.identifier.issn0002-9394
dc.identifier.issue4en_US
dc.identifier.pmid17011863en_US
dc.identifier.scopus2-s2.0-33748980786en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage673en_US
dc.identifier.urihttps://doi.org/10.1016/j.ajo.2006.05.003
dc.identifier.urihttps://hdl.handle.net/20.500.12491/5821
dc.identifier.volume142en_US
dc.identifier.wosWOS:000241098900022en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorTunç, Murat
dc.institutionauthorErbilen, Esin
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofAmerican Journal Of Ophthalmologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCombineden_US
dc.subjectMitomycin C
dc.subjectConjunctival
dc.subjectCorneal
dc.titleTopical cyclosporine-A combined with mitomycin C for conjunctival and corneal squamous cell carcinomaen_US
dc.typeArticleen_US

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